gptkbp:instanceOf
|
gptkb:drug
|
gptkbp:approvalYear
|
2020
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
|
gptkbp:ATCCode
|
J05AB16
|
gptkbp:bioavailability
|
low (prodrug)
|
gptkbp:CASNumber
|
1809249-37-3
|
gptkbp:clearanceBelow
|
70% renal (as metabolites)
|
gptkbp:contraindication
|
hypersensitivity to remdesivir
|
gptkbp:developer
|
gptkb:Gilead_Sciences
|
gptkbp:drugClass
|
antiviral drug
|
gptkbp:drugInteraction
|
chloroquine
hydroxychloroquine
|
gptkbp:eliminationHalfLife
|
1 hour (parent), 25 hours (metabolite)
|
gptkbp:form
|
solution for injection
|
gptkbp:hasBoxedWarning
|
none
|
gptkbp:hasFirstApprovalCountry
|
gptkb:Japan
|
gptkbp:hasFirstApprovalDate
|
May 2020
|
gptkbp:hasInChIKey
|
RWWYLEGWBNMMLJ-YSOARWBDSA-N
|
gptkbp:hasMolecularFormula
|
C27H35N6O8P
|
gptkbp:hasPatentHolder
|
gptkb:Gilead_Sciences
|
gptkbp:hasPharmacokinetics
|
prodrug, converted to active nucleoside triphosphate
|
gptkbp:hasPregnancyCategoryAU
|
gptkb:B3
|
gptkbp:hasPregnancyCategoryUS
|
Not assigned
|
gptkbp:hasResearchUse
|
gptkb:Marburg_virus_disease_(investigational)
gptkb:Ebola_virus_disease_(investigational)
|
gptkbp:hasSMILES
|
CC(C)[C@@H](NC(=O)[C@@H]1O[C@]([C@@H](O)[C@H](COP(=O)(O)O[C@H]2C[C@@H](N3C=NC4=C3N=CN=C4N)[C@H](O)[C@@H]2O)(C)O1)N)O)O
|
gptkbp:hasStorageCondition
|
store below 30°C
|
gptkbp:hasUNII
|
53J0WS6OJ7
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB14148
|
gptkbp:indication
|
treatment of COVID-19
|
gptkbp:legalStatus
|
prescription only
patented
|
gptkbp:mechanismOfAction
|
RNA polymerase inhibitor
|
gptkbp:metabolism
|
hepatic
|
gptkbp:molecularWeight
|
602.6 g/mol
|
gptkbp:name
|
gptkb:Remdesivir
|
gptkbp:pregnancyCategory
|
Not assigned
|
gptkbp:proteinBinding
|
88-93%
|
gptkbp:PubChem_CID
|
gptkb:DB14148
121304016
CHEMBL2016761
58191791
D11973
|
gptkbp:routeOfAdministration
|
intravenous
|
gptkbp:sideEffect
|
nausea
elevated liver enzymes
hypersensitivity
|
gptkbp:status
|
approved
|
gptkbp:synonym
|
gptkb:GS-5734
|
gptkbp:target
|
RNA-dependent RNA polymerase
|
gptkbp:therapeuticArea
|
gptkb:disease
|
gptkbp:toxicity
|
no data in overdose
|
gptkbp:bfsParent
|
gptkb:dextrorphan
|
gptkbp:bfsLayer
|
7
|