DB14148

GPTKB entity

Statements (55)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2020
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
gptkbp:ATCCode J05AB16
gptkbp:bioavailability low (prodrug)
gptkbp:CASNumber 1809249-37-3
gptkbp:clearanceBelow 70% renal (as metabolites)
gptkbp:contraindication hypersensitivity to remdesivir
gptkbp:developer gptkb:Gilead_Sciences
gptkbp:drugClass antiviral drug
gptkbp:drugInteraction chloroquine
hydroxychloroquine
gptkbp:eliminationHalfLife 1 hour (parent), 25 hours (metabolite)
gptkbp:form solution for injection
gptkbp:hasBoxedWarning none
gptkbp:hasFirstApprovalCountry gptkb:Japan
gptkbp:hasFirstApprovalDate May 2020
gptkbp:hasInChIKey RWWYLEGWBNMMLJ-YSOARWBDSA-N
gptkbp:hasMolecularFormula C27H35N6O8P
gptkbp:hasPatentHolder gptkb:Gilead_Sciences
gptkbp:hasPharmacokinetics prodrug, converted to active nucleoside triphosphate
gptkbp:hasPregnancyCategoryAU gptkb:B3
gptkbp:hasPregnancyCategoryUS Not assigned
gptkbp:hasResearchUse gptkb:Marburg_virus_disease_(investigational)
gptkb:Ebola_virus_disease_(investigational)
gptkbp:hasSMILES CC(C)[C@@H](NC(=O)[C@@H]1O[C@]([C@@H](O)[C@H](COP(=O)(O)O[C@H]2C[C@@H](N3C=NC4=C3N=CN=C4N)[C@H](O)[C@@H]2O)(C)O1)N)O)O
gptkbp:hasStorageCondition store below 30°C
gptkbp:hasUNII 53J0WS6OJ7
https://www.w3.org/2000/01/rdf-schema#label DB14148
gptkbp:indication treatment of COVID-19
gptkbp:legalStatus prescription only
patented
gptkbp:mechanismOfAction RNA polymerase inhibitor
gptkbp:metabolism hepatic
gptkbp:molecularWeight 602.6 g/mol
gptkbp:name gptkb:Remdesivir
gptkbp:pregnancyCategory Not assigned
gptkbp:proteinBinding 88-93%
gptkbp:PubChem_CID gptkb:DB14148
121304016
CHEMBL2016761
58191791
D11973
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
elevated liver enzymes
hypersensitivity
gptkbp:status approved
gptkbp:synonym gptkb:GS-5734
gptkbp:target RNA-dependent RNA polymerase
gptkbp:therapeuticArea gptkb:disease
gptkbp:toxicity no data in overdose
gptkbp:bfsParent gptkb:dextrorphan
gptkbp:bfsLayer 7