DB13963

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2020
gptkbp:ATCCode J05AB16
gptkbp:bioavailability Not orally bioavailable
gptkbp:brand gptkb:Veklury
gptkbp:CASNumber 1809249-37-3
gptkbp:contraindication hypersensitivity to remdesivir
gptkbp:developer gptkb:Gilead_Sciences
gptkbp:drugClass antiviral drug
gptkbp:eliminationHalfLife 1 hour (plasma), 25 hours (metabolite)
gptkbp:form solution for injection
lyophilized powder
gptkbp:hasAdministrationFrequency once daily
gptkbp:hasBoxedWarning nan
gptkbp:hasFirstApprovalCountry gptkb:United_States
gptkbp:hasFirstApprovalDate 2020-10-22
gptkbp:hasInChIKey RWWYLEGWBNMMLJ-YSOARWBDSA-N
gptkbp:hasMolecularFormula C27H35N6O8P
gptkbp:hasPatentExpiry 2035
gptkbp:hasPatentHolder gptkb:Gilead_Sciences
gptkbp:hasResearchUse gptkb:Marburg_virus_disease
gptkb:Ebola_virus_disease
gptkb:MERS-CoV_infection
gptkb:SARS-CoV_infection
gptkbp:hasSMILES CC(C)[C@@H](NC(=O)[C@@H](N)C(C)C)P(=O)(OCC1=CN(C2=NC=NC(=C21)N)C3CC3)OCC4=CC=CC=C4
gptkbp:hasStorageCondition Store below 30°C
gptkbp:hasUNII 0N1J5A44B2
https://www.w3.org/2000/01/rdf-schema#label DB13963
gptkbp:indication gptkb:COVID-19
gptkb:Ebola_virus_infection_(investigational)
gptkbp:legalStatus Prescription only
gptkbp:mechanismOfAction RNA-dependent RNA polymerase inhibitor
gptkbp:metabolism Hepatic
gptkbp:molecularWeight 602.6 g/mol
gptkbp:name gptkb:Remdesivir
gptkbp:pregnancyCategory Not assigned
gptkbp:PubChem_CID gptkb:DB13963
121304016
CHEMBL2016761
D11960
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
increased transaminases
gptkbp:status FDA approved
gptkbp:synonym gptkb:GS-5734
gptkbp:target gptkb:viral_RNA_polymerase
gptkbp:therapeuticArea gptkb:disease
gptkbp:bfsParent gptkb:Axicabtagene_ciloleucel
gptkb:Lutathera
gptkbp:bfsLayer 7