|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvalYear
|
2020
|
|
gptkbp:ATCCode
|
J05AB16
|
|
gptkbp:bioavailability
|
Low (IV only)
|
|
gptkbp:brand
|
gptkb:Veklury
|
|
gptkbp:CASNumber
|
1809249-37-3
|
|
gptkbp:contraindication
|
hypersensitivity to remdesivir
|
|
gptkbp:developer
|
gptkb:Gilead_Sciences
|
|
gptkbp:drugClass
|
antiviral drug
antiviral
|
|
gptkbp:eliminationHalfLife
|
1 hour (remdesivir), 25 hours (GS-441524)
|
|
gptkbp:excretion
|
Renal
|
|
gptkbp:form
|
solution for injection
lyophilized powder for injection
|
|
gptkbp:hasBoxedWarning
|
nan
|
|
gptkbp:hasFirstApprovalCountry
|
gptkb:United_States
|
|
gptkbp:hasFirstApprovalDate
|
2020-10-22
|
|
gptkbp:hasInChIKey
|
RWWYLEGWBNMMLJ-YSOARWBDSA-N
|
|
gptkbp:hasMolecularFormula
|
C27H35N6O8P
|
|
gptkbp:hasPatentHolder
|
gptkb:Gilead_Sciences
|
|
gptkbp:hasPharmacokinetics
|
rapidly converted to active nucleoside analog GS-441524
|
|
gptkbp:hasResearchUse
|
investigational for other viral infections
|
|
gptkbp:hasSMILES
|
CC(C)[C@@H](NC(=O)[C@@H](COP(=O)(OCC1=CN=CN1)OCC2=CN(C3=NC=NC(=C23)N)C)O)C(=O)N
|
|
gptkbp:hasStorageCondition
|
Refrigerated
|
|
gptkbp:hasUNII
|
53J0A36V2L
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB12189
|
|
gptkbp:indication
|
gptkb:COVID-19
gptkb:Ebola_virus_infection_(investigational)
|
|
gptkbp:legalStatus
|
patented
Prescription only
|
|
gptkbp:mechanismOfAction
|
RNA-dependent RNA polymerase inhibitor
|
|
gptkbp:metabolism
|
Hepatic
|
|
gptkbp:molecularWeight
|
602.6 g/mol
|
|
gptkbp:name
|
gptkb:Remdesivir
|
|
gptkbp:pregnancyCategory
|
Not assigned
|
|
gptkbp:PubChem_CID
|
gptkb:DB12189
121304016
CHEMBL2016761
D11960
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
nausea
elevated liver enzymes
hypersensitivity
|
|
gptkbp:status
|
FDA approved
|
|
gptkbp:structureType
|
prodrug
|
|
gptkbp:synonym
|
gptkb:GS-5734
|
|
gptkbp:target
|
RNA-dependent RNA polymerase
|
|
gptkbp:therapeuticArea
|
gptkb:disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
not listed
|
|
gptkbp:bfsParent
|
gptkb:151096-09-2
|
|
gptkbp:bfsLayer
|
6
|