DB11638

GPTKB entity

Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 2020
gptkbp:ATCCode J05AB16
gptkbp:bioavailability low (IV only)
gptkbp:CASNumber 1809249-37-3
gptkbp:contraindication hypersensitivity to remdesivir
gptkbp:developer gptkb:Gilead_Sciences
gptkbp:drugClass antiviral drug
gptkbp:halfLife 1 hour (remdesivir), 25 hours (GS-441524)
gptkbp:hasAdministrationForm solution for infusion
gptkbp:hasDrugType small molecule
gptkbp:hasEliminationRoute renal
gptkbp:hasFirstApprovalCountry gptkb:United_States
gptkbp:hasFirstApprovalDate 2020-10-22
gptkbp:hasInChIKey RWWYLEGWBNMMLJ-YSOARWBDSA-N
gptkbp:hasMolecularFormula C27H35N6O8P
gptkbp:hasResearchUse investigational for other viral infections
gptkbp:hasSMILES CC(C)[C@@H](NC(=O)[C@@H](N)C(C)C)P(=O)(OCC1=CN(C2=NC=NC(=C21)N)C3CC3)O
gptkbp:hasStorageCondition refrigerated
gptkbp:hasUNII 53J0A3T31J
https://www.w3.org/2000/01/rdf-schema#label DB11638
gptkbp:indication gptkb:COVID-19
gptkb:Ebola_virus_infection
gptkbp:legalStatus prescription only
patented
gptkbp:mechanismOfAction RNA polymerase inhibitor
gptkbp:metabolism hepatic
gptkbp:molecularWeight 602.6 g/mol
gptkbp:name gptkb:Remdesivir
gptkbp:pregnancyCategory Not assigned
gptkbp:PubChem_CID gptkb:DB11638
121304016
CHEMBL2016761
D11472
58170091
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect nausea
elevated liver enzymes
hypersensitivity
gptkbp:status FDA approved
gptkbp:synonym gptkb:GS-5734
gptkbp:target RNA-dependent RNA polymerase
gptkbp:therapeuticArea gptkb:disease
gptkbp:bfsParent gptkb:dihydroartemisinin
gptkbp:bfsLayer 6