|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvalYear
|
2020
|
|
gptkbp:ATCCode
|
J05AB16
|
|
gptkbp:bioavailability
|
low (intravenous only)
|
|
gptkbp:CASNumber
|
1809249-37-3
|
|
gptkbp:category
|
antiviral drugs
COVID-19 drugs
nucleotide analogues
|
|
gptkbp:contraindication
|
hypersensitivity to remdesivir
|
|
gptkbp:developer
|
gptkb:Gilead_Sciences
|
|
gptkbp:drugClass
|
antiviral drug
|
|
gptkbp:eliminationHalfLife
|
1 hour (parent), 25 hours (metabolite)
|
|
gptkbp:form
|
solution for infusion
|
|
gptkbp:hasInChIKey
|
RWWYLEGWBNMMLJ-YSOARWBDSA-N
|
|
gptkbp:hasMolecularFormula
|
C27H35N6O8P
|
|
gptkbp:hasSMILES
|
CC(C)[C@@H](NC(=O)[C@@H]1O[C@H](n2cnc3c(N)ncnc32)[C@@H](O)[C@H]1O)P(=O)(O)OCCOCCO
|
|
gptkbp:hasStorageCondition
|
store below 30°C
|
|
gptkbp:hasUNII
|
53J0A3T31S
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB11630
|
|
gptkbp:indication
|
gptkb:COVID-19
gptkb:Ebola_virus_infection
|
|
gptkbp:legalStatus
|
prescription only
patented
|
|
gptkbp:mechanismOfAction
|
RNA polymerase inhibitor
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
602.6 g/mol
|
|
gptkbp:name
|
gptkb:Remdesivir
|
|
gptkbp:pregnancyCategory
|
Not assigned (US)
|
|
gptkbp:PubChem_CID
|
gptkb:DB11630
121304016
CHEMBL2016761
D11472
58191716
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
nausea
elevated liver enzymes
hypersensitivity
|
|
gptkbp:status
|
FDA approved
EMA approved
|
|
gptkbp:synonym
|
gptkb:GS-5734
|
|
gptkbp:target
|
RNA-dependent RNA polymerase
|
|
gptkbp:bfsParent
|
gptkb:avermectin_B1a
|
|
gptkbp:bfsLayer
|
7
|