|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:ATCCode
|
A03AE01
|
|
gptkbp:bioavailability
|
10%
|
|
gptkbp:CASNumber
|
189188-57-6
|
|
gptkbp:category
|
gptkb:gastroprokinetic_agent
gptkb:serotonin_receptor_agonist
|
|
gptkbp:contraindication
|
severe renal impairment
severe hepatic impairment
history of bowel obstruction
ischemic colitis
|
|
gptkbp:drugClass
|
increases gastrointestinal motility
|
|
gptkbp:eliminationHalfLife
|
11 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:hasInChIKey
|
QYJXJQFZJZTXHB-IZZDOVSWSA-N
|
|
gptkbp:hasMolecularFormula
|
C16H19N3O3S
|
|
gptkbp:hasReintroduction
|
restricted access program (US, 2008)
|
|
gptkbp:hasSMILES
|
CCCCCNS(=O)(=O)C1=CC=C(C=C1OC)N=CC2=CN=CN2C
|
|
gptkbp:hasUNII
|
K8L3F7C5PO
|
|
gptkbp:indication
|
chronic idiopathic constipation
irritable bowel syndrome with constipation
|
|
gptkbp:isWithdrawn
|
yes
|
|
gptkbp:IUPACName
|
(Z)-5-methoxy-2-[(5-methyl-1H-imidazol-4-yl)methyleneamino]-N-pentylbenzene-1-sulfonamide
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Novartis
|
|
gptkbp:mechanismOfAction
|
5-HT4 receptor partial agonist
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:molecularWeight
|
333.41
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:proteinBinding
|
98%
|
|
gptkbp:PubChem_CID
|
gptkb:DB08604
CHEMBL1201192
159869
D04719
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
diarrhea
abdominal pain
headache
|
|
gptkbp:status
|
yes
|
|
gptkbp:synonym
|
Tegaserod
|
|
gptkbp:bfsParent
|
gptkb:triclosan
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DB08604
|