CpG Island Methylator Phenotype
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological phenotype
|
| gptkbp:abbreviation |
gptkb:CIMP
|
| gptkbp:associatedWith |
gptkb:endometrial_cancer
colorectal cancer DNA methylation gastric cancer glioma BRAF mutation microsatellite instability |
| gptkbp:characterizedBy |
widespread hypermethylation of CpG islands
|
| gptkbp:discoveredBy |
gptkb:Jean-Pierre_Issa
|
| gptkbp:firstDescribed |
1999
|
| gptkbp:hasBiomarker |
MINT loci methylation
MLH1 promoter methylation p16INK4a methylation |
| https://www.w3.org/2000/01/rdf-schema#label |
CpG Island Methylator Phenotype
|
| gptkbp:impact |
gene expression
tumor progression |
| gptkbp:relatedTo |
epigenetics
tumorigenesis |
| gptkbp:studiedIn |
cancer epigenetics
|
| gptkbp:bfsParent |
gptkb:CIMP
|
| gptkbp:bfsLayer |
7
|