Corey– Ziegler– Yamamoto reaction
GPTKB entity
Statements (45)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:chemical_compound
|
| gptkbp:application |
materials science
pharmaceutical chemistry polymer chemistry |
| gptkbp:benefits |
high selectivity
requires specialized equipment limited substrate scope mild reaction conditions potential for side reactions requires expensive reagents |
| gptkbp:developed_by |
gptkb:Robert_Ziegler
gptkb:Yamamoto gptkb:Elias_J._Corey |
| gptkbp:dissolved |
can be performed in DMF
can be performed in DMSO often performed in toluene |
| gptkbp:first_described_by |
gptkb:1980s
|
| https://www.w3.org/2000/01/rdf-schema#label |
Corey– Ziegler– Yamamoto reaction
|
| gptkbp:involves |
halogenated compounds
organometallic reagents |
| gptkbp:is_essential_for |
organic synthesis
|
| gptkbp:mechanism_of_action |
involves oxidative addition
involves reductive elimination |
| gptkbp:notable_contributor |
gptkb:salt
metal halide organic halide |
| gptkbp:produces |
biaryl products
|
| gptkbp:related_to |
gptkb:Negishi_reaction
Suzuki reaction Stille reaction |
| gptkbp:requires |
gptkb:military_base
|
| gptkbp:sensitivity |
requires careful handling
sensitive to air sensitive to moisture |
| gptkbp:type |
cross-coupling reaction
|
| gptkbp:used_for |
synthesis of biaryl compounds
|
| gptkbp:was_a_catalyst_for |
palladium
|
| gptkbp:was_a_response_to |
coupling reaction
an inert atmosphere involves coordination complex formation involves ligand exchange involves bond formation involves transition state formation |
| gptkbp:bfsParent |
gptkb:Elias_James_Corey
|
| gptkbp:bfsLayer |
5
|