Corey– Ziegler– Tsuji reaction
GPTKB entity
Statements (44)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:chemical_compound
|
| gptkbp:bfsLayer |
5
|
| gptkbp:bfsParent |
gptkb:Elias_James_Corey
gptkb:E._J._Corey |
| gptkbp:application |
materials science
organic synthesis medicinal chemistry polymer chemistry |
| gptkbp:applies_to |
aryl halides
aryl boronic acids |
| gptkbp:benefits |
high selectivity
broad substrate scope mild reaction conditions potential for side reactions cost of palladium requires air-free conditions |
| gptkbp:developed_by |
1970s
|
| gptkbp:fuel_type |
palladium(0) complexes
palladium(II) complexes ligands required |
| https://www.w3.org/2000/01/rdf-schema#label |
Corey– Ziegler– Tsuji reaction
|
| gptkbp:involves |
organometallic compounds
|
| gptkbp:is_essential_for |
synthesis of pharmaceuticals
synthesis of natural products material science applications |
| gptkbp:named_after |
gptkb:E._J._Corey
gptkb:H._Ziegler T. Tsuji |
| gptkbp:produced_by |
biaryl compounds
|
| gptkbp:related_to |
gptkb:Negishi_reaction
Suzuki reaction Stille reaction |
| gptkbp:suitable_for |
aliphatic compounds
heteroaryl compounds complex substrates |
| gptkbp:type |
cross-coupling reaction
|
| gptkbp:uses |
palladium catalysts
|
| gptkbp:was_a_response_to |
base required
involves oxidative addition involves reductive elimination involves transmetalation temperature control necessary solvent choice important time of reaction variable |