Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:artemether
|
| gptkbp:activities |
inhibits parasite growth
artemisinin derivative |
| gptkbp:age |
adults
children over 5 kg |
| gptkbp:approves |
gptkb:2001
gptkb:World_Health_Organization |
| gptkbp:availability |
prescription only
|
| gptkbp:category |
gptkb:C
|
| gptkbp:clinical_trial |
extensively studied
first-line treatment in many countries |
| gptkbp:contains |
gptkb:artemether
gptkb:lumefantrine |
| gptkbp:contraindication |
hypersensitivity to artemether or lumefantrine
|
| gptkbp:distribution |
widely used in endemic areas
|
| gptkbp:dosage_form |
fixed-dose combination
based on body weight |
| gptkbp:duration |
3 days
|
| gptkbp:education |
inform about potential side effects
advise on adherence to regimen |
| gptkbp:excretion |
primarily through feces
some renal excretion |
| gptkbp:form |
tablets
suspension oral tablet |
| gptkbp:formulation |
combination therapy
|
| gptkbp:healthcare |
important in malaria control efforts
|
| https://www.w3.org/2000/01/rdf-schema#label |
Coartem
|
| gptkbp:impact |
significantly reduced malaria mortality
|
| gptkbp:interacts_with |
may interact with certain antiretroviral drugs
may interact with some anticonvulsants |
| gptkbp:invention |
patented
|
| gptkbp:is_effective_against |
high against Plasmodium falciparum
effective in uncomplicated malaria |
| gptkbp:is_monitored_by |
requires monitoring of heart rate
|
| gptkbp:is_used_for |
treatment of malaria
|
| gptkbp:latest_version |
gptkb:stock_market_index
|
| gptkbp:lifespan |
approximately 3 days
|
| gptkbp:marketed_as |
gptkb:Novartis
|
| gptkbp:partnerships |
collaborates with health organizations
|
| gptkbp:pharmacokinetics |
included
metabolized in the liver rapid absorption |
| gptkbp:price |
varies by region
|
| gptkbp:provides_information_on |
recommended by WHO
|
| gptkbp:research |
ongoing studies for new formulations
|
| gptkbp:safety_features |
generally well tolerated
|
| gptkbp:shelf_life |
24 months
|
| gptkbp:side_effect |
fatigue
headache nausea vomiting rarely causes severe reactions |
| gptkbp:storage |
store below 30° C
|
| gptkbp:treatment |
low in endemic regions
|
| gptkbp:water_resistance |
limited resistance reported
|