Chlorpromazine hydrochloride

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
antipsychotic medication
gptkbp:ATCCode N05AA01
gptkbp:belongs_to_class phenothiazines
gptkbp:CASNumber 69-09-0
gptkbp:cause QT prolongation
neuroleptic malignant syndrome
tardive dyskinesia
gptkbp:chemicalFormula C17H20ClN3S·HCl
gptkbp:contraindication gptkb:pheochromocytoma
bone marrow depression
severe CNS depression
gptkbp:discoveredBy gptkb:Paul_Charpentier
gptkbp:eliminationHalfLife 16-30 hours
gptkbp:excretion urine
bile
gptkbp:first_marketed_in 1953
gptkbp:has_black_box_warning increased mortality in elderly patients with dementia-related psychosis
https://www.w3.org/2000/01/rdf-schema#label Chlorpromazine hydrochloride
gptkbp:IUPACName 2-chloro-N,N-dimethyl-10H-phenothiazine-10-ethanamine hydrochloride
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction dopamine D2 receptor antagonist
antagonist at histamine H1 receptors
antagonist at muscarinic acetylcholine receptors
gptkbp:meltingPoint 195-198°C
gptkbp:metabolism liver
gptkbp:molecularWeight 355.33 g/mol
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID 71416
CHEBI:3647
DB00477
gptkbp:routeOfAdministration oral
intramuscular
intravenous
gptkbp:sideEffect weight gain
hypotension
sedation
photosensitivity
extrapyramidal symptoms
anticholinergic effects
gptkbp:synonym gptkb:Largactil
gptkb:Thorazine
gptkbp:UNII U3P01618RT
gptkbp:usedFor nausea
schizophrenia
vomiting
psychotic disorders
severe behavioral problems in children
manic phase of bipolar disorder
gptkbp:bfsParent gptkb:Thorazine
gptkbp:bfsLayer 6