Statements (80)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:activated_form |
gptkb:C5b
|
| gptkbp:associated_with |
inflammatory response
|
| gptkbp:cleaved_into |
gptkb:C5a
gptkb:C5b |
| gptkbp:clinical_trial |
target for therapeutic intervention
|
| gptkbp:discovered_by |
1970s
|
| gptkbp:ecological_role |
gptkb:neurodegenerative_diseases
autoimmune diseases sepsis infections complement deficiencies |
| gptkbp:function |
part of the complement system
|
| https://www.w3.org/2000/01/rdf-schema#label |
C5
|
| gptkbp:initiated_by |
gptkb:eculizumab
gptkb:ravulizumab C5 convertase C5a receptor antagonists |
| gptkbp:interacts_with |
gptkb:C8
gptkb:C9 C7 C6 |
| gptkbp:involved_in |
gptkb:paroxysmal_nocturnal_hemoglobinuria
immune response allergic reactions inflammation wound healing B cell activation T cell activation pathogen recognition acute inflammation chronic inflammation tissue damage phagocytosis tissue repair viral infections adaptive immunity opsonization graft rejection cellular signaling vaccine response tumor immunity innate immunity antibody production ischemia-reperfusion injury chemokine production chemotaxis atypical hemolytic uremic syndrome cell lysis immune surveillance neutrophil activation thrombotic microangiopathy immunological memory transfusion reactions host defense mechanisms immune cell recruitment cytokine release monocyte activation autoimmune hemolytic anemia macrophage activation complement activation pathways C5 deficiency C5a receptor signaling C5b-9 complex formation alternative pathway bacterial clearance classical pathway dendritic cell activation immune complex clearance lectin pathway |
| gptkbp:located_in |
blood plasma
|
| gptkbp:produced_by |
liver
|
| gptkbp:promoter |
C5 gene
|
| gptkbp:subunit |
two chains (C5a and C5b)
|
| gptkbp:targets |
C5 inhibitors
|
| gptkbp:weight |
approximately 190 k Da
|
| gptkbp:bfsParent |
gptkb:Deidara
gptkb:Audi_A6 gptkb:Sauber |
| gptkbp:bfsLayer |
5
|