|
gptkbp:instanceOf
|
local anesthetic
|
|
gptkbp:affiliatedWith
|
amide-type local anesthetics
|
|
gptkbp:antidote
|
lipid emulsion therapy
|
|
gptkbp:approvedBy
|
1972 (US)
|
|
gptkbp:aroma
|
odorless
|
|
gptkbp:ATCCode
|
N01BB01
|
|
gptkbp:CASNumber
|
38396-39-3
|
|
gptkbp:chemicalFormula
|
C18H28N2O
|
|
gptkbp:color
|
white (as powder)
|
|
gptkbp:contraindication
|
hypersensitivity to amide anesthetics
|
|
gptkbp:discoveredBy
|
gptkb:Astra_AB
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:eliminationHalfLife
|
2.7 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasEnantiomer
|
levobupivacaine
|
|
gptkbp:hasLogP
|
3.64
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Bupivacaine
|
|
gptkbp:IUPACName
|
(RS)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
|
|
gptkbp:KEGGID
|
D07513
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:meltingPoint
|
107–108 °C
|
|
gptkbp:MeSH_ID
|
D001831
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
288.43 g/mol
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:pKa
|
8.1
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:proteinBinding
|
95%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL472
2474
DB00297
|
|
gptkbp:riskFactor
|
gptkb:methemoglobinemia
seizures
cardiotoxicity
|
|
gptkbp:routeOfAdministration
|
injection
|
|
gptkbp:sideEffect
|
gptkb:arrhythmia
allergic reaction
hypotension
bradycardia
CNS toxicity
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:synonym
|
Marcaine
Sensorcaine
Vivacaine
|
|
gptkbp:UNII
|
Y8335394RO
|
|
gptkbp:usedFor
|
spinal anesthesia
local anesthesia
epidural anesthesia
nerve block
|
|
gptkbp:bfsParent
|
gptkb:Anesthetic
|
|
gptkbp:bfsLayer
|
7
|