Bicalutamide

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
nonsteroidal antiandrogen
gptkbp:approvedBy gptkb:Australia
gptkb:European_Union
gptkb:Japan
gptkb:United_States
1995
gptkbp:ATCCode gptkb:L02BB03
gptkbp:bioavailability almost complete
gptkbp:brand Casodex
Calutide
Bicalutamid
gptkbp:CASNumber 90357-06-5
gptkbp:chemicalFormula C18H14F4N2O4S
gptkbp:contraindication gptkb:women
children
pregnancy
gptkbp:developedBy gptkb:AstraZeneca
gptkbp:discoveredIn 1980s
gptkbp:drugClass hormonal antineoplastic agent
antiandrogen
gptkbp:eliminationHalfLife 5–7 days
gptkbp:excretion urine
feces
gptkbp:hasEnantiomer (R)-bicalutamide
(S)-bicalutamide
https://www.w3.org/2000/01/rdf-schema#label Bicalutamide
gptkbp:KEGGID D00294
gptkbp:legalStatus prescription only
gptkbp:listedOn gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:mechanismOfAction androgen receptor antagonist
gptkbp:metabolism liver
gptkbp:molecularWeight 430.38 g/mol
gptkbp:pregnancyCategory D
nan
X
X (contraindicated)
gptkbp:proteinBinding 96%
gptkbp:PubChem_CID gptkb:CHEMBL1423
2375
DB01128
gptkbp:routeOfAdministration oral
gptkbp:sideEffect liver toxicity
gynecomastia
hot flashes
sexual dysfunction
gptkbp:synonym IUPAC: N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide
gptkbp:UNII 81X0L3H3BG
gptkbp:usedFor prostate cancer
gptkbp:bfsParent gptkb:VESTANAT
gptkbp:bfsLayer 8