Barton-McCombie deoxygenation
GPTKB entity
Statements (25)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:chemical_compound
|
gptkbp:alsoKnownAs |
gptkb:Barton_deoxygenation
|
gptkbp:alternativeTo |
tris(trimethylsilyl)silane
phosphorus hydrides |
gptkbp:application |
total synthesis
natural product synthesis |
gptkbp:category |
name reaction in organic chemistry
deoxygenation reaction |
gptkbp:convertedTo |
alcohol to alkane
|
gptkbp:discoveredIn |
1975
|
https://www.w3.org/2000/01/rdf-schema#label |
Barton-McCombie deoxygenation
|
gptkbp:keyIntermediate |
xanthate ester
thionoester |
gptkbp:mechanismOfAction |
radical chain mechanism
|
gptkbp:namedAfter |
gptkb:Derek_Barton
gptkb:Stuart_W._McCombie |
gptkbp:reactant |
gptkb:AIBN
tributyltin hydride |
gptkbp:removesFunctionalGroup |
hydroxyl group
|
gptkbp:riskFactor |
tributyltin hydride is toxic
|
gptkbp:step |
alcohol converted to xanthate ester
xanthate ester reduced to alkane |
gptkbp:type |
radical reaction
|
gptkbp:bfsParent |
gptkb:Derek_Barton
|
gptkbp:bfsLayer |
6
|