Barton-McCombie deoxygenation

GPTKB entity

Statements (25)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:alsoKnownAs gptkb:Barton_deoxygenation
gptkbp:alternativeTo tris(trimethylsilyl)silane
phosphorus hydrides
gptkbp:application total synthesis
natural product synthesis
gptkbp:category name reaction in organic chemistry
deoxygenation reaction
gptkbp:convertedTo alcohol to alkane
gptkbp:discoveredIn 1975
https://www.w3.org/2000/01/rdf-schema#label Barton-McCombie deoxygenation
gptkbp:keyIntermediate xanthate ester
thionoester
gptkbp:mechanismOfAction radical chain mechanism
gptkbp:namedAfter gptkb:Derek_Barton
gptkb:Stuart_W._McCombie
gptkbp:reactant gptkb:AIBN
tributyltin hydride
gptkbp:removesFunctionalGroup hydroxyl group
gptkbp:riskFactor tributyltin hydride is toxic
gptkbp:step alcohol converted to xanthate ester
xanthate ester reduced to alkane
gptkbp:type radical reaction
gptkbp:bfsParent gptkb:Derek_Barton
gptkbp:bfsLayer 6