|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:administeredBy
|
oral
|
|
gptkbp:approvedBy
|
gptkb:European_Union
2014 (EU)
|
|
gptkbp:ATCCode
|
M09AX03
|
|
gptkbp:CASNumber
|
775304-57-9
|
|
gptkbp:compatibleWith
|
gptkb:United_States
|
|
gptkbp:contraindication
|
hypersensitivity to ataluren
|
|
gptkbp:developedBy
|
gptkb:PTC_Therapeutics
|
|
gptkbp:discoveredBy
|
gptkb:PTC_Therapeutics
|
|
gptkbp:hasInChIKey
|
QXMYGJIEJZVQSK-UHFFFAOYSA-N
|
|
gptkbp:hasMolecularFormula
|
C15H9FN2O3
|
|
gptkbp:hasSMILES
|
C1=CC(=CC=C1C2=NC(=O)C(=C(O2)C3=CC=C(C=C3)F)N)O
|
|
gptkbp:indication
|
nonsense mutation Duchenne muscular dystrophy
|
|
gptkbp:legalStatus
|
prescription only (EU)
|
|
gptkbp:marketedAs
|
gptkb:Translarna
|
|
gptkbp:mechanismOfAction
|
promotes ribosomal readthrough of premature stop codons
|
|
gptkbp:molecularWeight
|
284.24 g/mol
|
|
gptkbp:patent
|
gptkb:PTC_Therapeutics
|
|
gptkbp:pregnancyCategory
|
not recommended
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL2103837
11295732
9461450
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
diarrhea
headache
|
|
gptkbp:target
|
nonsense mutations
|
|
gptkbp:UNII
|
6HG8UB2MUY
|
|
gptkbp:usedFor
|
treatment of Duchenne muscular dystrophy
|
|
gptkbp:bfsParent
|
gptkb:CFTR
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ataluren
|