Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:biotechnology
|
| gptkbp:acquisition |
Aprea Therapeutics acquired by another company
|
| gptkbp:business_model |
biotech innovation
|
| gptkbp:can_lead_to |
gptkb:APR-246
|
| gptkbp:ceo |
Shankar Musunuri
|
| gptkbp:clinical_trial |
gptkb:Phase_4
Phase 1 multiple locations patient recruitment Phase 2 Phase 3 safety and efficacy solid tumors randomized controlled trial safety profile overall survival adaptive trial design promising efficacy Phase 0 targeting p53 pathway |
| gptkbp:collaboration |
academic institutions
|
| gptkbp:collaborations |
biotech firms
clinical research organizations international research groups |
| gptkbp:drug_candidate |
gptkb:APR-246
|
| gptkbp:drug_discovery |
novel compounds
|
| gptkbp:drug_mechanism |
reactivation of mutant p53
|
| gptkbp:drug_target |
p53 protein
|
| gptkbp:focus |
cancer therapeutics
|
| gptkbp:founded |
gptkb:2010
|
| gptkbp:funding |
Series B funding
government grants |
| gptkbp:has_advisory_board |
experts in oncology
|
| gptkbp:headquarters |
gptkb:Boston,_Massachusetts
|
| gptkbp:healthcare |
oral administration
FDA approval process |
| https://www.w3.org/2000/01/rdf-schema#label |
Aprea Therapeutics
|
| gptkbp:instruction_set |
cancer drugs
|
| gptkbp:investment |
gptkb:public_company
Venture capital institutional investors |
| gptkbp:investment_focus |
biopharmaceuticals
|
| gptkbp:is_tested_for |
p53 status
|
| gptkbp:partnership |
gptkb:Merck_&_Co.
pharmaceutical companies |
| gptkbp:product |
gptkb:APR-246
|
| gptkbp:publication |
peer-reviewed journals
|
| gptkbp:regulatory_compliance |
gptkb:FDA
|
| gptkbp:research_areas |
oncology
p53 mutations restoring p53 function |
| gptkbp:research_focus |
cancer genetics
hematologic malignancies |
| gptkbp:research_initiative |
cancer research funding
|
| gptkbp:stock_exchange |
gptkb:NASDAQ
|
| gptkbp:therapeutic_application |
combination therapy
|
| gptkbp:therapeutic_goal |
improve survival rates
|
| gptkbp:therapeutic_strategy |
targeted therapy
|
| gptkbp:treatment |
patient response
|
| gptkbp:type_of |
gptkb:pharmaceuticals
|
| gptkbp:website |
www.apreatx.com
|
| gptkbp:bfsParent |
gptkb:Hikma_Pharmaceuticals
|
| gptkbp:bfsLayer |
5
|