AIDS resistance (CCR5-Δ32 mutation)
GPTKB entity
Statements (18)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
genetic trait
|
| gptkbp:associatedWith |
CCR5 gene
|
| gptkbp:awardedBy |
CCR5-Δ32 mutation
|
| gptkbp:discoveredIn |
1996
|
| gptkbp:effect |
heterozygous individuals partially resistant to HIV-1
homozygous individuals highly resistant to HIV-1 |
| gptkbp:frequency |
about 1% homozygous in some European populations
|
| https://www.w3.org/2000/01/rdf-schema#label |
AIDS resistance (CCR5-Δ32 mutation)
|
| gptkbp:inheritance |
autosomal recessive
|
| gptkbp:mechanismOfAction |
prevents HIV from entering immune cells
|
| gptkbp:mutationAssociatedWith |
32 base pair deletion
|
| gptkbp:prevalence |
highest in Northern European populations
|
| gptkbp:relatedTo |
HIV/AIDS research
|
| gptkbp:resistantTo |
HIV-1 infection
|
| gptkbp:studiedBy |
gptkb:Stephen_O'Brien
|
| gptkbp:usedIn |
bone marrow transplantation for HIV cure
|
| gptkbp:bfsParent |
gptkb:chromosome_3_(human)
|
| gptkbp:bfsLayer |
7
|