9-[(2-hydroxyethoxy)methyl]guanine

URI: https://gptkb.org/entity/9-[(2-hydroxyethoxy)methyl]guanine
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
antiviral drug
gptkbp:approvedBy gptkb:FDA
1981
gptkbp:ATCCode J05AB01
gptkbp:CASNumber 59277-89-3
gptkbp:category antiviral drug
purine analogue
gptkbp:chemicalFormula C8H11N5O3
gptkbp:discoveredBy gptkb:George_H._Hitchings
gptkb:Gertrude_B._Elion
gptkb:Howard_Schaeffer
gptkbp:eliminationHalfLife 2–3 hours
gptkbp:excretion renal
https://www.w3.org/2000/01/rdf-schema#label 9-[(2-hydroxyethoxy)methyl]guanine
gptkbp:IUPACName 2-amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits viral DNA polymerase
gptkbp:meltingPoint 256–257 °C
gptkbp:metabolism liver
gptkbp:molecularWeight 225.21 g/mol
gptkbp:otherName gptkb:Acyclovir
gptkbp:routeOfAdministration oral
topical
intravenous
gptkbp:sideEffect nausea
vomiting
diarrhea
headache
neutropenia
renal dysfunction
gptkbp:usedFor herpes simplex virus infection
varicella zoster virus infection
gptkbp:bfsParent gptkb:acyclovir
gptkbp:bfsLayer 6