1448221-59-6

URI: https://gptkb.org/entity/1448221-59-6
GPTKB entity
Statements (30)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:administeredBy intravenous infusion
gptkbp:approvedBy gptkb:FDA
2020
gptkbp:ATCCode J05AB16
gptkbp:CASNumber gptkb:1448221-59-6
gptkbp:developedBy gptkb:Gilead_Sciences
gptkbp:eliminatedIn renal
gptkbp:halfLife 1 hour (plasma), 25 hours (active metabolite)
gptkbp:hasMolecularFormula C27H35N6O8P
gptkbp:hasSMILES CC(C)[C@@H](NC(=O)[C@H]1O[C@@](CN2C=NC3=C2N=CN=C3N)([C@@H](O1)COC4=CC=CC=C4OP(=O)(O)O)C#N)C(=O)O
gptkbp:hasUNII R7MMO2FK01
https://www.w3.org/2000/01/rdf-schema#label 1448221-59-6
gptkbp:isAntiviralDrug true
gptkbp:IUPACName (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction RNA polymerase inhibitor
gptkbp:molecularWeight 602.6 g/mol
gptkbp:prodrugOf gptkb:GS-441524
gptkbp:PubChem_CID 121304016
DB14761
CHEMBL2016761
gptkbp:sideEffect nausea
elevated liver enzymes
allergic reactions
gptkbp:synonym gptkb:Remdesivir
gptkbp:usedFor gptkb:COVID-19
gptkb:Ebola_virus_disease
gptkbp:bfsParent gptkb:Atezolizumab
gptkbp:bfsLayer 6