1140077-05-6

URI: https://gptkb.org/entity/1140077-05-6

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:chemical_compound
gptkbp:approvalYear	2020
gptkbp:approvedBy	gptkb:FDA gptkb:EMA
gptkbp:ATCCode	J05AB16
gptkbp:CASNumber	gptkb:1140077-05-6
gptkbp:developedBy	gptkb:Gilead_Sciences
gptkbp:drugClass	antiviral
gptkbp:eliminationHalfLife	1 hour (parent), 25 hours (metabolite)
gptkbp:hasMolecularFormula	C27H35N6O8P
gptkbp:hasSMILES	CC(C)[C@@H](NC(=O)[C@H]1O[C@@](CN2C=NC3=C2N=CN=C3N)([C@@H](O)[C@H]1O)CO[P@@](=O)(OCCOC(=O)C(C)C)O)O
gptkbp:hasUNII	R7MMO9464A
https://www.w3.org/2000/01/rdf-schema#label	1140077-05-6
gptkbp:IUPACName	(2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	RNA polymerase inhibitor
gptkbp:metabolism	hydrolysis and phosphorylation
gptkbp:molecularWeight	602.6 g/mol
gptkbp:pregnancyCategory	not recommended
gptkbp:PubChem_CID	121304016 DB14761 CHEMBL2016761
gptkbp:routeOfAdministration	intravenous
gptkbp:sideEffect	nausea elevated liver enzymes allergic reactions
gptkbp:synonym	gptkb:Remdesivir
gptkbp:usedFor	gptkb:COVID-19 gptkb:Ebola_virus_disease
gptkbp:bfsParent	gptkb:Zulresso
gptkbp:bfsLayer	6