Triple

T23399830
Position Surface form Disambiguated ID Type / Status
Subject CYP2D6 E559472 entity
Predicate fullName P16 FINISHED
Object cytochrome P450 family 2 subfamily D member 6
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) is a highly polymorphic liver enzyme that metabolizes a wide range of clinically important drugs, significantly influencing individual responses to medications.
E1583714 NE FINISHED

How this triple was built (4 steps)

Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.

NER Named-entity recognition gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: cytochrome P450 family 2 subfamily D member 6 | Statement: [CYP2D6, fullName, cytochrome P450 family 2 subfamily D member 6]
NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07
Target entity: cytochrome P450 family 2 subfamily D member 6
Context triple: [CYP2D6, fullName, cytochrome P450 family 2 subfamily D member 6]
  • A. cytochrome P450 family 2 subfamily C member 19
    Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) is a liver enzyme that metabolizes various clinically important drugs, including proton pump inhibitors, antidepressants, and the antiplatelet agent clopidogrel, with genetic variants significantly affecting individual drug response.
  • B. CYP2J2
    CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
  • C. CYP2B6
    CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
  • D. CYP3A4
    CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
  • E. cytochrome P450 superfamily
    The cytochrome P450 superfamily is a large and diverse group of heme-containing enzymes that catalyze the oxidation of a wide variety of endogenous compounds and xenobiotics, playing key roles in drug metabolism and biosynthesis of hormones and lipids.
  • F. None of above. chosen
  • G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg Description generation gpt-5.1
Instruction
Generate a one-sentence description of the target entity. 
You are given a context triple in the form (subject, predicate, object), where the object is the target entity. 
# Instructions
Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. 
Avoid repeating the information from the triple, unless really essential.
# Response Format
Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: cytochrome P450 family 2 subfamily D member 6
Triple: [CYP2D6, fullName, cytochrome P450 family 2 subfamily D member 6]
Generated description
Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) is a highly polymorphic liver enzyme that metabolizes a wide range of clinically important drugs, significantly influencing individual responses to medications.
NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07
Target entity: cytochrome P450 family 2 subfamily D member 6
Target entity description: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) is a highly polymorphic liver enzyme that metabolizes a wide range of clinically important drugs, significantly influencing individual responses to medications.
  • A. cytochrome P450 family 2 subfamily C member 19
    Cytochrome P450 family 2 subfamily C member 19 (CYP2C19) is a liver enzyme that metabolizes various clinically important drugs, including proton pump inhibitors, antidepressants, and the antiplatelet agent clopidogrel, with genetic variants significantly affecting individual drug response.
  • B. CYP2J2
    CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
  • C. CYP2B6
    CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
  • D. CYP3A4
    CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
  • E. cytochrome P450 superfamily
    The cytochrome P450 superfamily is a large and diverse group of heme-containing enzymes that catalyze the oxidation of a wide variety of endogenous compounds and xenobiotics, playing key roles in drug metabolism and biosynthesis of hormones and lipids.
  • F. None of above. chosen

Provenance (5 batches)

The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.

Step Stage Batch ID Status When
creating Elicitation batch_69e24549610c8190a069d6411ce5f661 completed April 17, 2026, 2:35 p.m.
NER Named-entity recognition batch_69f1a4dedfcc8190ab93cec3c3d15c53 completed April 29, 2026, 6:27 a.m.
NED1 Entity disambiguation (via context triple) batch_6a0c5df194bc819084aa4de85966c68f completed May 19, 2026, 12:56 p.m.
NEDg Description generation batch_6a0c5f52fe308190b87c53f9a9d915e0 completed May 19, 2026, 1:02 p.m.
NED2 Entity disambiguation (via description) batch_6a0c5ffbea40819088a5a01a3763c718 completed May 19, 2026, 1:05 p.m.
Created at: April 17, 2026, 5:37 p.m.