Triple
T22690408
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | selpercatinib |
E561034
|
entity |
| Predicate | target |
P860
|
FINISHED |
| Object |
RET kinase
RET kinase is a receptor tyrosine kinase involved in cell growth and differentiation whose activating alterations drive several cancers, making it an important therapeutic target.
|
E1549328
|
NE FINISHED |
How this triple was built (4 steps)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
NER
Named-entity recognition
gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: RET kinase | Statement: [selpercatinib, target, RET kinase]
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: RET kinase Context triple: [selpercatinib, target, RET kinase]
-
A.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
D.
CaMKII
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
-
E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NEDg
Description generation
gpt-5.1
Instruction
Generate a one-sentence description of the target entity. You are given a context triple in the form (subject, predicate, object), where the object is the target entity. # Instructions Use the triple to infer relevant information about the entity. Describe the entity based on what is most defining, well-known. Avoid repeating the information from the triple, unless really essential. # Response Format Return only the sentence: "Description: [one-sentence description of the target entity]"
Input
Entity: RET kinase Triple: [selpercatinib, target, RET kinase]
Generated description
RET kinase is a receptor tyrosine kinase involved in cell growth and differentiation whose activating alterations drive several cancers, making it an important therapeutic target.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: RET kinase Target entity description: RET kinase is a receptor tyrosine kinase involved in cell growth and differentiation whose activating alterations drive several cancers, making it an important therapeutic target.
-
A.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
D.
CaMKII
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
-
E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
Provenance (5 batches)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69e2454d71b48190a1f80af9f82b6fcf |
completed | April 17, 2026, 2:35 p.m. |
| NER | Named-entity recognition | batch_69f1789a1fd08190bce5fa0babe695d3 |
completed | April 29, 2026, 3:18 a.m. |
| NED1 | Entity disambiguation (via context triple) | batch_6a0b73fa5a648190b90ba303d1fe2397 |
completed | May 18, 2026, 8:18 p.m. |
| NEDg | Description generation | batch_6a0b7755eb048190ba1657a9a09bc24b |
completed | May 18, 2026, 8:32 p.m. |
| NED2 | Entity disambiguation (via description) | batch_6a0b780c0a4c8190b51b50c1e0e1a114 |
completed | May 18, 2026, 8:35 p.m. |
Created at: April 17, 2026, 3:13 p.m.