Triple
T20301045
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | Tagrisso |
E505479
|
entity |
| Predicate | instanceOf |
P0
|
FINISHED |
| Object | tyrosine kinase inhibitor |
C43617
|
CONCEPT FINISHED |
How this triple was built (1 step)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
CD
Concept disambiguation
gpt-5-mini-2025-08-07
Target class: tyrosine kinase inhibitor Context triple: [Tagrisso, instanceOf, tyrosine kinase inhibitor]
-
A.
receptor tyrosine kinase
A receptor tyrosine kinase is a transmembrane protein that, upon binding an extracellular ligand, dimerizes and autophosphorylates its intracellular tyrosine residues to initiate intracellular signaling cascades regulating cell growth, differentiation, and survival.
-
B.
Janus kinase inhibitor
A Janus kinase inhibitor is a drug that selectively blocks Janus kinase (JAK) enzymes to modulate cytokine signaling and reduce inflammation or abnormal immune activity in various diseases.
-
C.
angiopoietin-2 inhibitor
An angiopoietin-2 inhibitor is a therapeutic agent that selectively blocks the activity of angiopoietin-2 to stabilize blood vessels, reduce pathological angiogenesis, and modulate vascular inflammation in diseases such as cancer and ocular disorders.
-
D.
Bruton tyrosine kinase inhibitor
A Bruton tyrosine kinase inhibitor is a targeted small-molecule drug that blocks BTK signaling in B cells to disrupt pathways critical for their activation, proliferation, and survival, primarily used in the treatment of certain B-cell malignancies and autoimmune diseases.
-
E.
CDK4/6 inhibitor
A CDK4/6 inhibitor is a targeted anticancer drug that blocks cyclin-dependent kinases 4 and 6 to halt cell cycle progression from G1 to S phase, thereby inhibiting tumor cell proliferation.
- F. None of above. chosen
Provenance (1 batch)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69e0b4b8ab648190906e18538c250148 |
completed | April 16, 2026, 10:06 a.m. |
Created at: April 16, 2026, 11:17 a.m.