valproate

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instance_of gptkb:chemical_compound
gptkbp:approves gptkb:FDA
gptkbp:associated_with polycystic ovary syndrome
neural tube defects
gptkbp:atccode N03 AG01
gptkbp:available_on oral tablet
oral solution
injectable form
gptkbp:brand Depakote
Epival
Depakene
gptkbp:casnumber 99-66-1
gptkbp:category gptkb:D
gptkbp:chemical_formula C8 H16 N2 O2
gptkbp:class gptkb:Antihero
mood stabilizer
gptkbp:contraindication liver disease
urea cycle disorders
gptkbp:discovered_by 1960s
gptkbp:dosage_form 10-60 mg/kg/day
gptkbp:drug_interactions gptkb:phenobarbital
gptkb:lamotrigine
gptkb:carbamazepine
gptkb:warfarin
aspirin
gptkbp:duration varies by condition
gptkbp:excretion urine
feces
https://www.w3.org/2000/01/rdf-schema#label valproate
gptkbp:is_monitored_by liver function tests
blood levels
gptkbp:lifespan 9 to 16 hours
gptkbp:mechanism_of_action increases GABA levels
gptkbp:metabolism liver
gptkbp:side_effect nausea
liver damage
weight gain
hair loss
tremor
gptkbp:suitable_for pregnant women
breastfeeding women
children under 2 years
gptkbp:symptoms confusion
drowsiness
respiratory depression
coma
gptkbp:treatment gptkb:epilepsy
bipolar disorder
migraine prophylaxis
gptkbp:used_for treating epilepsy
treating bipolar disorder
preventing migraine headaches
gptkbp:bfsParent gptkb:carbamazepine
gptkbp:bfsLayer 5