|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:approves
|
gptkb:1970
gptkb:FDA
|
|
gptkbp:atccode
|
J01 EA01
|
|
gptkbp:brand
|
gptkb:Bactrim
gptkb:Septra
|
|
gptkbp:can_be_combined_with
|
gptkb:sulfamethoxazole
|
|
gptkbp:casnumber
|
738-70-5
|
|
gptkbp:chemical_formula
|
C14 H18 N4 O3 S
|
|
gptkbp:clinical_use
|
gptkb:pneumonia
respiratory infections
otitis media
urinary tract infections
gastrointestinal infections
|
|
gptkbp:contraindication
|
pregnancy
renal impairment
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:formulation
|
gptkb:tablet
suspension
injection
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
trimethoprim
|
|
gptkbp:interacts_with
|
gptkb:methotrexate
gptkb:phenytoin
gptkb:warfarin
|
|
gptkbp:lifespan
|
8-10 hours
|
|
gptkbp:mechanism_of_action
|
inhibits bacterial dihydrofolate reductase
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:route_of_administration
|
oral
intravenous
|
|
gptkbp:side_effect
|
nausea
rash
itching
|
|
gptkbp:targets
|
gptkb:Escherichia_coli
gptkb:Haemophilus_influenzae
gptkb:Klebsiella_pneumoniae
gptkb:Proteus_mirabilis
gptkb:Staphylococcus_aureus
|
|
gptkbp:used_for
|
bacterial infections
|
|
gptkbp:bfsParent
|
gptkb:trimethoprim-sulfamethoxazole
|
|
gptkbp:bfsLayer
|
6
|