Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
chemical compound
|
| gptkbp:associated_with |
high electronegativity
|
| gptkbp:contains |
one carbon atom
three fluorine atoms |
| gptkbp:depicts |
-CF3
|
| gptkbp:features |
many natural products
many agrochemicals many drug candidates many fluorinated compounds many industrial chemicals many specialty chemicals many synthetic intermediates |
| https://www.w3.org/2000/01/rdf-schema#label |
trifluoromethyl group
|
| gptkbp:is_a_key_component_of |
trifluoromethylated amino acids
trifluoromethylated heterocycles trifluoromethylated peptides trifluoromethylated polymers trifluoromethylbenzene |
| gptkbp:is_a_symbol_of |
organic compounds
|
| gptkbp:is_involved_in |
fluorination reactions
|
| gptkbp:is_known_for |
enhancing metabolic stability
increasing lipophilicity modifying biological activity |
| gptkbp:is_part_of |
trifluoromethylated compounds
trifluoromethylated drugs trifluoromethylated fungicides trifluoromethylated herbicides trifluoromethylated insecticides trifluoromethylated pesticides |
| gptkbp:is_used_in |
materials science
pharmaceuticals synthesis of pharmaceuticals synthesis of agrochemicals agrochemicals fluorinated agrochemicals fluorinated lubricants fluorinated materials fluorinated pharmaceuticals fluorinated solvents fluorinated surfactants |
| gptkbp:knownFor |
improve pharmacokinetics
improve selectivity reduce toxicity affect binding affinity affect electronic properties affect permeability affect solubility enhance bioavailability increase chemical stability increase potency influence reaction pathways stabilize radical intermediates |