telomerase reverse transcriptase
GPTKB entity
Statements (174)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
gptkb:Biology |
| gptkbp:activities |
decreases with age
|
| gptkbp:application |
anti-aging therapies
aging studies |
| gptkbp:associated_with |
apoptosis regulation
cell differentiation cell proliferation DNA repair mechanisms cellular senescence genomic stability chronic inflammation cancer stem cells telomere shortening therapeutic resistance telomere maintenance genetic predisposition to cancer cellular repair processes telomere length cellular rejuvenation age-related decline telomere biology research telomere syndromes proliferation of germ cells chromosomal integrity stem cell renewal telomere length maintenance |
| gptkbp:benefits |
cellular therapy
cellular rejuvenation therapies telomere extension |
| gptkbp:breeding_range |
chromosome 5
|
| gptkbp:catalytic_activity |
reverse transcription
|
| gptkbp:cell_cycle_regulation |
active in S phase
|
| gptkbp:cellular_localization |
cytoplasm and nucleus
|
| gptkbp:clinical_trial |
biomarker for cancer
ongoing for cancer therapies |
| gptkbp:code |
telomerase enzyme
|
| gptkbp:discovered_by |
gptkb:1980s
gptkb:Elizabeth_Blackburn 1970s |
| gptkbp:diseases |
pulmonary fibrosis
certain cancers dyskeratosis congenita |
| gptkbp:ecological_role |
telomere elongation
|
| gptkbp:expression_in |
gptkb:Cell
cancer cells embryonic cells germ cells |
| gptkbp:expression_patterns |
varies in different tissues
|
| gptkbp:function |
adds DNA sequence repeats to the ends of chromosomes
|
| gptkbp:gene_delivery_methods_include |
viral vectors
|
| gptkbp:gene_therapy_approaches_include |
gptkb:CRISPR_technology
|
| gptkbp:genetic_studies |
telomere shortening
dyskeratosis congenita associated with certain cancers highly conserved among species |
| gptkbp:has_role |
cancer development
cellular metabolism immune response genomic stability tissue regeneration cellular signaling cellular repair mechanisms cellular growth |
| https://www.w3.org/2000/01/rdf-schema#label |
telomerase reverse transcriptase
|
| gptkbp:influences |
stem cell maintenance
|
| gptkbp:inhibitor_examples |
gptkb:Imetelstat
|
| gptkbp:inhibitors_developed_for |
gptkb:cancer_treatment
|
| gptkbp:inhibitory_compounds |
GRN163 L
|
| gptkbp:inhibitory_mechanism |
telomere shortening
|
| gptkbp:initiated_by |
gptkb:T-TRF1
gptkb:T-TRF1/2/3 gptkb:T-TRF1/2/3/4 gptkb:T-TRF1/2/3/5 gptkb:T-TRF1/2/3/7 gptkb:T-TRF2 gptkb:Imetelstat gptkb:OBP-301 apoptosis potential cancer therapies MST-312 T-IMT T-oligo TL-32711 apoptosis in cancer cells telomerase inhibitors BIBR1532 GRN163 L T-TRF1/2 T-TRF1/2/3/10 T-TRF1/2/3/11 T-TRF1/2/3/12 T-TRF1/2/3/13 T-TRF1/2/3/14 T-TRF1/2/3/15 T-TRF1/2/3/16 T-TRF1/2/3/17 T-TRF1/2/3/18 T-TRF1/2/3/19 T-TRF1/2/3/20 T-TRF1/2/3/6 T-TRF1/2/3/8 T-TRF1/2/3/9 |
| gptkbp:interacts_with |
gptkb:telomerase_RNA_component
RNA component of telomerase |
| gptkbp:involved_in |
cancer development
cell differentiation cellular homeostasis cellular stress response tissue engineering DNA repair mechanisms tumorigenesis cellular aging cellular signaling pathways stem cell maintenance cellular adaptation metabolic regulation cell immortalization |
| gptkbp:is_expressed_in |
gptkb:Cell
germ cells varies by tissue type varies during development upregulated in many tumors |
| gptkbp:is_found_in |
eukaryotic cells
human genome |
| gptkbp:is_linked_to |
genetic disorders
stem cell therapy chronic diseases genetic engineering therapeutic cloning cancer prevention strategies cellular differentiation pathways proliferation of cells therapeutic interventions for aging |
| gptkbp:is_located_in |
chromosome 5
|
| gptkbp:is_studied_for |
therapeutic interventions
therapeutic efficacy longevity research |
| gptkbp:is_studied_in |
molecular biology
clinical trials regenerative medicine aging research |
| gptkbp:is_targeted_at |
gptkb:gene_therapy
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:notable_applications |
gptkb:biotechnology
gene therapy research gene editing |
| gptkbp:notable_work |
linked to immortality of cancer cells
|
| gptkbp:nutritional_value |
homodimer
|
| gptkbp:originated_in |
TERC
|
| gptkbp:overexpressed_in |
tumor cells
|
| gptkbp:post_translational_modifications |
phosphorylation
|
| gptkbp:potential_risks_include |
tumorigenesis
|
| gptkbp:potential_use_in |
anti-aging therapies
cancer immunotherapy gene replacement therapy |
| gptkbp:promoter |
gptkb:TERT
|
| gptkbp:regulates |
cell cycle
|
| gptkbp:regulatory_compliance |
telomerase RNA
|
| gptkbp:related_to |
gptkb:telomerase
|
| gptkbp:research |
CRISPR gene editing
telomere biology |
| gptkbp:research_focus |
telomere biology
|
| gptkbp:role |
cellular aging
cancer cell immortality |
| gptkbp:structure |
reverse transcriptase domain
|
| gptkbp:subunit |
TERT protein
|
| gptkbp:targets |
gptkb:cancer_treatment
cancer therapy anti-cancer drugs |
| gptkbp:theory |
RNA template
|
| gptkbp:therapeutic_strategies_include |
telomerase activation
|
| gptkbp:therapeutic_target_for |
age-related diseases
|
| gptkbp:weight |
approximately 125 k Da
|