superoxide dismutase 1 protein
GPTKB entity
Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
studied in oxidative stress research
|
| gptkbp:binding_site |
contains a metal-binding site
|
| gptkbp:biochemical_pathway |
involved in reactive oxygen species detoxification
|
| gptkbp:breeding_range |
chromosome 21
|
| gptkbp:catalytic_activity |
2 O2-+ 2 H+ -> O2 + H2 O2
|
| gptkbp:cellular_function |
protects against oxidative damage
|
| gptkbp:clinical_importance |
important in aging research
|
| gptkbp:clinical_trial |
biomarker for neurodegenerative diseases
investigated for gene therapy ongoing trials for ALS therapies |
| gptkbp:clinical_use |
potential for gene therapy in ALS
|
| gptkbp:discovered_by |
Irwin Fridovich and Joe Mc Cord
|
| gptkbp:diseases |
gptkb:amyotrophic_lateral_sclerosis
|
| gptkbp:dissolved |
soluble in cytosol
|
| gptkbp:ecological_role |
protects cells from oxidative stress
reduces superoxide toxicity |
| gptkbp:enzyme_classification |
EC 1.15.1.1
|
| gptkbp:enzyme_type |
antioxidant enzyme
|
| gptkbp:financial_stability |
affected by mutations
|
| gptkbp:function |
catalyzes the dismutation of superoxide into oxygen and hydrogen peroxide
|
| gptkbp:function_in_disease |
implicated in neurodegeneration
|
| gptkbp:gene_expression |
upregulated in response to stress
|
| gptkbp:gene_therapy_research |
explored for treatment of neurodegenerative diseases
|
| gptkbp:genetic_studies |
missense mutations
linked to familial ALS loss of function leads to disease |
| gptkbp:homologs |
SOD2, SOD3
|
| https://www.w3.org/2000/01/rdf-schema#label |
superoxide dismutase 1 protein
|
| gptkbp:inhibitory_mechanism |
inhibited by high concentrations of superoxide
|
| gptkbp:initiated_by |
azide
|
| gptkbp:interacts_with |
interacts with other antioxidant enzymes
|
| gptkbp:is_expressed_in |
gptkb:Brain
|
| gptkbp:location |
cytosol
|
| gptkbp:modifications |
phosphorylation
|
| gptkbp:nutritional_value |
X-ray crystallography studies
antioxidant enzymes catalyzes the conversion of superoxide radicals. superoxide dismutase family interacts with HSP70 |
| gptkbp:pathway |
antioxidant defense
|
| gptkbp:promoter |
gptkb:SOD1
|
| gptkbp:protein_source |
found in various tissues
|
| gptkbp:protein_stability |
affected by environmental factors
|
| gptkbp:regulatory_compliance |
regulated by oxidative stress levels
|
| gptkbp:research_areas |
target for antioxidant therapies
|
| gptkbp:research_focus |
studied for its role in ALS
|
| gptkbp:research_importance |
key in understanding oxidative stress
|
| gptkbp:role_in_cell |
maintains redox balance
|
| gptkbp:structure |
homodimer
|
| gptkbp:subunit |
two identical subunits
|
| gptkbp:targets |
potential target for ALS treatment
|
| gptkbp:theory |
copper and zinc
|
| gptkbp:type |
metalloenzyme
|
| gptkbp:weight |
approximately 32 k Da
|
| gptkbp:bfsParent |
gptkb:SOD1_gene_mutations
|
| gptkbp:bfsLayer |
5
|