Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:affects |
red blood cells
|
| gptkbp:associated_with |
sickle cell trait
|
| gptkbp:caused_by |
mutation in HBB gene
|
| gptkbp:clinical_trial |
ongoing for new treatments
exploring new drug therapies investigating gene editing techniques studying pain management strategies testing stem cell therapies |
| gptkbp:community_impact |
affects millions worldwide
significant health burden in endemic regions |
| gptkbp:community_support |
gptkb:fundraising_events
advocacy initiatives educational workshops awareness campaigns patient support groups |
| gptkbp:complication |
stroke
pulmonary hypertension organ damage acute chest syndrome |
| gptkbp:cultural_impact |
influences music and art
promotes research funding raises awareness in communities |
| gptkbp:diagnosis |
newborn screening
hemoglobin electrophoresis |
| gptkbp:educational_resources |
gptkb:healthcare_professionals
community outreach programs patient advocacy groups |
| gptkbp:historical_context |
associated with malaria resistance
first described in 1910 |
| https://www.w3.org/2000/01/rdf-schema#label |
sickle cell disease
|
| gptkbp:inherits_from |
autosomal recessive
|
| gptkbp:is_involved_in |
gptkb:Sickle_Cell_Society
gptkb:Sickle_Cell_Disease_Association_of_America gptkb:Sickle_Cell_Foundation |
| gptkbp:lifespan |
reduced compared to general population
|
| gptkbp:prevalence |
more common in African descent
more common in Mediterranean descent more common in Middle Eastern descent |
| gptkbp:public_awareness |
September
|
| gptkbp:research_focus |
gptkb:gene_therapy
new medications pain management |
| gptkbp:symptoms |
gptkb:anemia
frequent infections pain crises swelling in hands and feet |
| gptkbp:treatment |
bone marrow transplant
hydroxyurea blood transfusions |
| gptkbp:bfsParent |
gptkb:Sangamo_Therapeutics
gptkb:Vertex_Pharmaceuticals gptkb:St._Jude_Children's_Research_Hospital gptkb:CRISPR-Cas9 gptkb:CRISPR_technology |
| gptkbp:bfsLayer |
4
|