myeloid-derived suppressor cells
GPTKB entity
Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:smartphone
|
| gptkbp:associated_with |
autoimmune diseases
tumor microenvironment chronic inflammation viral infections metastasis bacterial infections tumor angiogenesis parasitic infections |
| gptkbp:can_create |
C D11b
Gr-1 |
| gptkbp:function |
suppress immune responses
|
| https://www.w3.org/2000/01/rdf-schema#label |
myeloid-derived suppressor cells
|
| gptkbp:increased |
cytokines
|
| gptkbp:influence |
immune evasion
B cell function dendritic cell function |
| gptkbp:is_aimed_at |
vaccines
monoclonal antibodies small molecule inhibitors immune checkpoint inhibitors |
| gptkbp:is_effective_against |
T cell activation
|
| gptkbp:is_found_in |
bone marrow
tumor tissues peripheral blood |
| gptkbp:is_involved_in |
allergy responses
tolerance induction |
| gptkbp:origin |
myeloid lineage
|
| gptkbp:participated_in |
growth factors
hypoxia hormones exosomes damaged tissues chemokines stress signals extracellular vesicles tumor-associated macrophages apoptotic cells cellular debris inflammatory mediators microbial products necrotic cells nutrient deprivation tumor-associated dendritic cells tumor-associated fibroblasts tumor-associated neutrophils tumor-derived factors |
| gptkbp:produced_by |
gptkb:nitric_oxide
arginase |
| gptkbp:reduces |
gptkb:vaccine
radiation therapy chemotherapy |
| gptkbp:role |
cancer progression
|
| gptkbp:targets |
natural killer cells
T regulatory cells |
| gptkbp:type_of |
granulocytic MDS Cs
monocytic MDS Cs |
| gptkbp:bfsParent |
gptkb:PD-L2
|
| gptkbp:bfsLayer |
6
|