Statements (78)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
studied in neurodegenerative diseases
studied in virology |
| gptkbp:associated_with |
gptkb:Oncology
ribosome assembly m RNA cap structure translation initiation complex e IF4 F complex |
| gptkbp:clinical_trial |
target for cancer therapy
|
| gptkbp:family |
DEAD-box helicases
|
| gptkbp:function |
involved in the initiation of translation
|
| https://www.w3.org/2000/01/rdf-schema#label |
e IF4 A
|
| gptkbp:importance |
critical for cap-dependent translation
|
| gptkbp:initiated_by |
small molecule inhibitors
rocaglamide silvestrol e IF4 A inhibitors |
| gptkbp:interacts_with |
e IF4 E
e IF4 G |
| gptkbp:involved_in |
gptkb:embryonic_development
metabolism apoptosis cell cycle regulation cell differentiation cell proliferation cellular homeostasis cellular stress response developmental processes immune response lipid metabolism neurotransmitter release protein synthesis signal transduction inflammation wound healing muscle development stress response cell survival synaptic plasticity cellular aging xenobiotic metabolism protein degradation neural development angiogenesis gene expression regulation immune cell activation tissue repair protein folding carbohydrate metabolism viral replication cellular signaling pathways autophagy stem cell maintenance protein-protein interactions nucleotide metabolism cellular repair mechanisms metabolic regulation hormonal signaling cellular detoxification stress granule formation translation regulation protein modification cytokine signaling stress adaptation m RNA stability protein-lipid interactions protein-nucleic acid interactions translation elongation |
| gptkbp:is_expressed_in |
upregulated in various cancers
|
| gptkbp:location |
cytoplasm
|
| gptkbp:modifications |
phosphorylation
acetylation |
| gptkbp:orthologs |
found in many eukaryotic organisms
|
| gptkbp:promoter |
EIF4 A1
|
| gptkbp:role |
RNA binding
|
| gptkbp:structure |
contains a helicase domain
|
| gptkbp:bfsParent |
gptkb:PDCD4
|
| gptkbp:bfsLayer |
7
|