Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:limb-girdle_muscular_dystrophy_type_2_A
gptkb:muscular_dystrophy metabolic disorders chronic diseases muscle regeneration inflammatory responses cardiac muscle function dystrophinopathies muscle fiber repair mechanisms muscle fiber type composition muscle function preservation muscle injury recovery |
| gptkbp:challenges |
leads to muscle weakness
|
| gptkbp:clinical_trial |
biomarker for muscle diseases
ongoing for therapeutic targets |
| gptkbp:discovered_by |
1990s
|
| gptkbp:enzyme_type |
calcium-dependent cysteine protease
|
| gptkbp:field_of_study |
molecular biology
|
| gptkbp:function |
involved in muscle development
regulates cytoskeletal proteins |
| gptkbp:genetic_studies |
causes muscle disorders
|
| https://www.w3.org/2000/01/rdf-schema#label |
calpain 3
|
| gptkbp:influences |
muscle hypertrophy
|
| gptkbp:inhibition |
can prevent muscle degeneration
|
| gptkbp:initiated_by |
are being developed
calpain inhibitors requires calcium ions |
| gptkbp:interacts_with |
other calpains
|
| gptkbp:involved_in |
cell cycle regulation
cell signaling cellular homeostasis signal transduction cellular signaling pathways protein turnover protein synthesis regulation cellular stress responses protein quality control cellular remodeling processes muscle fiber remodeling myofibrillar disassembly |
| gptkbp:is_expressed_in |
regulated by calcium levels
high in skeletal muscle varies with muscle type |
| gptkbp:is_found_in |
muscle tissues
|
| gptkbp:is_linked_to |
muscle atrophy
muscle cell differentiation exercise adaptations exercise-induced adaptations neuromuscular junction integrity |
| gptkbp:is_recognized_by |
gene sequencing
|
| gptkbp:is_studied_for |
therapeutic interventions
gene therapy approaches biomarker development potential drug targets understanding muscle diseases |
| gptkbp:is_studied_in |
animal models
clinical trials |
| gptkbp:location |
skeletal muscle
|
| gptkbp:orthologs |
found in various species
|
| gptkbp:pathway |
calcium signaling pathway
|
| gptkbp:promoter |
gptkb:CAPN3
|
| gptkbp:related_to |
muscle repair
|
| gptkbp:role |
protein degradation
in apoptosis |
| gptkbp:subunit |
composed of large and small subunits
|
| gptkbp:bfsParent |
gptkb:CAPN3
|
| gptkbp:bfsLayer |
6
|