anaplastic lymphoma kinase protein
GPTKB entity
Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:healthcare_organization
gptkb:neuroblastoma |
| gptkbp:clinical_trial |
biomarker for cancer
target for targeted therapy prognostic factor |
| gptkbp:established |
gptkb:brigatinib
gptkb:lorlatinib gptkb:alectinib gptkb:ceritinib gptkb:crizotinib |
| gptkbp:function |
tyrosine kinase activity
|
| gptkbp:genetic_diversity |
F1174 L
G1269 A K1154 R N1202 I R1275 Q |
| https://www.w3.org/2000/01/rdf-schema#label |
anaplastic lymphoma kinase protein
|
| gptkbp:interacts_with |
EM L4
NP M1 |
| gptkbp:is_a_route_for |
MAPK signaling pathway
Ras signaling pathway Wnt signaling pathway JAK-STAT signaling pathway P I3 K-Akt signaling pathway |
| gptkbp:is_represented_in |
associated with poor prognosis
associated with resistance to therapy overexpressed in tumors detected in normal tissues |
| gptkbp:location |
cytoplasm
cell membrane |
| gptkbp:promoter |
gptkb:ALK
|
| gptkbp:research |
target for drug development
biomarker for treatment response potential for combination therapy investigated in clinical trials analyzed for genetic alterations analyzed for its role in apoptosis analyzed for its structural properties characterized for functional studies characterized for its enzymatic activity evaluated for diagnostic purposes explored for its role in metastasis explored for therapeutic targets investigated for signaling pathways role in oncogenesis studied for its evolutionary conservation studied for its interaction with other proteins studied for its role in cell proliferation studied for resistance mechanisms investigated for its role in tumor microenvironment explored for its potential in personalized medicine |
| gptkbp:social_responsibility |
gptkb:healthcare_organization
gptkb:neuroblastoma |
| gptkbp:bfsParent |
gptkb:ALK
|
| gptkbp:bfsLayer |
5
|