Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:Company
|
| gptkbp:application |
agricultural biotechnology
functional genomics therapeutic development |
| gptkbp:benefits |
versatility
off-target effects high specificity complex design process |
| gptkbp:composedOf |
zinc finger proteins
nuclease domain |
| gptkbp:developedBy |
biotechnology companies
|
| https://www.w3.org/2000/01/rdf-schema#label |
Zinc Finger Nucleases
|
| gptkbp:improves |
genome editing precision
|
| gptkbp:isUsedFor |
study gene function
create transgenic organisms create animal models insert genes knock out genes modify gene expression develop disease-resistant plants study genetic diseases analyze gene regulatory elements create disease models create gene knock-ins create knockout mice develop gene therapies edit animal genomes edit plant genomes enhance crop traits facilitate gene delivery generate stable cell lines investigate gene interactions modify endogenous genes perform gene therapy perform genome-wide screens perform targeted mutagenesis produce genetically modified organisms target specific DNA sequences |
| gptkbp:isVisitedBy |
1990s
|
| gptkbp:patentCitation |
various institutions
|
| gptkbp:relatedTo |
CRISPR technology
TALENs |
| gptkbp:requires |
design of zinc finger proteins
nuclease engineering |
| gptkbp:targets |
customizable
|
| gptkbp:triggerType |
homologous recombination
non-homologous end joining double-strand breaks |
| gptkbp:usedFor |
gene editing
|
| gptkbp:usedIn |
clinical trials
research laboratories |