Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:application |
agricultural biotechnology
therapeutic development |
| gptkbp:associated_with |
genome editing
|
| gptkbp:available_at |
viral vectors
liposomes electroporation microinjection |
| gptkbp:benefits |
high precision
potential off-target effects |
| gptkbp:can_be_combined_with |
other gene editing technologies
|
| gptkbp:can_be_designed_to_target |
specific genes
|
| gptkbp:can_be_used_in |
animal models
human cells plant models |
| gptkbp:can_be_used_to_insert |
reporter genes
|
| gptkbp:can_be_used_to_modify |
endogenous genes
|
| gptkbp:can_be_used_to_repair |
mutated genes
|
| gptkbp:can_create |
knockout organisms
transgenic organisms gene knockouts animal models of disease knock-in organisms |
| gptkbp:composed_of |
zinc finger proteins
nuclease domain |
| gptkbp:developed_by |
1990s
biotechnology companies disease-resistant plants |
| gptkbp:enhances |
crop traits
|
| gptkbp:has_applications_in |
gptkb:biotechnology
genetic disorders cancer research |
| https://www.w3.org/2000/01/rdf-schema#label |
Zinc Finger Nucleases
|
| gptkbp:improves |
protein engineering
|
| gptkbp:invention |
various inventors
|
| gptkbp:involves |
DNA repair mechanisms
|
| gptkbp:is_analyzed_in |
gene regulation
functional genomics pathway functions |
| gptkbp:is_explored_in |
genetic pathways
|
| gptkbp:is_regulated_by |
government agencies
|
| gptkbp:is_studied_for |
gene function
protein interactions |
| gptkbp:is_tested_for |
gene therapies.
|
| gptkbp:mechanism_of_action |
double-strand breaks in DNA
|
| gptkbp:related_to |
gptkb:CRISPR_technology
|
| gptkbp:requires |
delivery systems
|
| gptkbp:targets |
customizable
|
| gptkbp:used_for |
gene editing
|
| gptkbp:used_in |
research laboratories
|
| gptkbp:used_in_clinical_trials |
gptkb:gene_therapy
|
| gptkbp:bfsParent |
gptkb:Sangamo_Therapeutics
gptkb:CRISPR-Cas9 |
| gptkbp:bfsLayer |
4
|