Statements (63)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:historical_event
schizophrenia anxiety disorders neuroinflammation neurite outgrowth neuronal survival autism spectrum disorders neurotrophic factor signaling |
| gptkbp:clinical_trial |
potential therapeutic target
involved in neurodegenerative diseases associated with cancer progression |
| gptkbp:community |
immune response in the CNS
glial cell function |
| gptkbp:discovered_by |
gptkb:Dr._Louis_Reichardt
|
| gptkbp:established |
Trk C-Fc
|
| gptkbp:function |
neurotrophic signaling
|
| https://www.w3.org/2000/01/rdf-schema#label |
Trk C receptor
|
| gptkbp:intelligence |
NTRK C3 in humans
Ntrk3 in mice Ntrk3 in rats |
| gptkbp:interacts_with |
gptkb:Trk_A_receptor
gptkb:Trk_B_receptor |
| gptkbp:is_a_route_for |
MAPK/ ERK pathway
P I3 K/ Akt pathway PL Cγ pathway |
| gptkbp:is_affected_by |
on apoptosis
|
| gptkbp:is_involved_in |
cell differentiation
cell proliferation neurotransmitter release neuroplasticity synaptic plasticity neurogenesis neurotransmission neuroprotection cell migration development of the nervous system synaptic transmission learning and memory neurodevelopmental processes axon guidance myelination neuronal repair neurotrophic signaling pathways neurotrophic factor-mediated signaling neurotrophic factor receptor interactions neurotrophic factor signaling pathways neurotrophic factor-induced signaling |
| gptkbp:is_represented_in |
in the spinal cord
in the brain |
| gptkbp:location |
gptkb:computer
|
| gptkbp:products |
gptkb:neurotrophin-3
|
| gptkbp:promoter |
NTRK C3
|
| gptkbp:promotes |
cell survival
differentiation of neurons |
| gptkbp:role |
pain modulation
sensory neuron function |
| gptkbp:type |
tyrosine kinase receptor
|
| gptkbp:type_of |
Trk C1
Trk C2 |
| gptkbp:year_created |
1990s
|
| gptkbp:bfsParent |
gptkb:Trk_A_receptor
|
| gptkbp:bfsLayer |
5
|