Statements (65)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:depression
gptkb:neurodegenerative_diseases schizophrenia anxiety disorders cancer progression pain signaling autism spectrum disorders |
| gptkbp:function |
gptkb:fusion
|
| https://www.w3.org/2000/01/rdf-schema#label |
Trk A receptor
|
| gptkbp:initiated_by |
NGF binding
Trk inhibitors |
| gptkbp:interacts_with |
gptkb:Trk_B_receptor
gptkb:Trk_C_receptor |
| gptkbp:involved_in |
gptkb:embryonic_development
apoptosis regulation cell differentiation cell proliferation immune response neurotransmitter release wound healing neuroinflammation neuroplasticity stress response cell signaling pathways pain perception synaptic plasticity tissue repair cell adhesion cell migration hormonal regulation neuroendocrine signaling synaptic transmission neurite outgrowth axon regeneration neuronal survival learning and memory metabolic regulation pain modulation axon guidance dendritic growth signal transduction. extracellular matrix interaction stress adaptation cellular response to stimuli neural crest cell migration myelination neurotrophic signaling cell-cell communication circadian rhythm regulation neurotrophic factor signaling sensory neuron development adult neurogenesis cell survival signaling motor neuron development |
| gptkbp:is_expressed_in |
gptkb:Brain
glial cells |
| gptkbp:knockouts |
nerve growth factor (NGF)
|
| gptkbp:located_in |
cell membrane
|
| gptkbp:promoter |
gptkb:NTRK1
|
| gptkbp:role |
central nervous system development
peripheral nervous system development |
| gptkbp:type |
tyrosine kinase receptor
|
| gptkbp:bfsParent |
gptkb:Nerve_growth_factor
|
| gptkbp:bfsLayer |
5
|