Statements (66)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:chronic_fatigue_syndrome
gptkb:neurodegenerative_diseases mental health cognitive function cardiovascular health diabetes management autoimmune disorders cobalamin metabolism |
| gptkbp:clinical_relevance |
important in prenatal health
|
| gptkbp:clinical_trial |
important for elderly populations
marker for vitamin B12 deficiency |
| gptkbp:diseases |
homocystinuria
|
| gptkbp:function |
transport of vitamin B12
|
| gptkbp:genetic_studies |
can cause impaired vitamin B12 transport
|
| https://www.w3.org/2000/01/rdf-schema#label |
Transcobalamin II
|
| gptkbp:influences |
cellular homeostasis
cholesterol metabolism energy metabolism metabolic pathways protein synthesis immune function oxidative stress response cellular aging red blood cell production hormonal balance neurological function homocysteine levels methylation processes |
| gptkbp:interacts_with |
cell surface receptors
|
| gptkbp:involved_in |
cell signaling
cellular respiration lipid metabolism DNA synthesis cellular differentiation protein metabolism nucleotide synthesis cellular repair mechanisms cellular uptake of vitamin B12 metabolism of folate |
| gptkbp:is_found_in |
human body
extracellular fluid blood plasma cerebrospinal fluid tissues throughout the body |
| gptkbp:is_tested_for |
measured in serum
|
| gptkbp:knockouts |
high for vitamin B12
|
| gptkbp:location |
gptkb:plasma
|
| gptkbp:pathway |
vitamin B12 transport pathway
|
| gptkbp:produced_by |
liver
|
| gptkbp:promoter |
TCN2
|
| gptkbp:related_to |
chronic diseases
metabolic syndrome neurotransmitter synthesis vitamin B12 absorption transcobalamin I transcobalamin III vitamin B12 deficiency anemia |
| gptkbp:role |
binding to vitamin B12
|
| gptkbp:structure |
contains a single polypeptide chain
|
| gptkbp:symptoms |
can lead to megaloblastic anemia
|
| gptkbp:synthesis_location |
intestinal mucosa
|
| gptkbp:transportation |
endocytosis
|
| gptkbp:weight |
approximately 38 k Da
|
| gptkbp:bfsParent |
gptkb:Vitaminwater
|
| gptkbp:bfsLayer |
4
|