Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Clinical_Trials
|
| gptkbp:age_group |
50 years and older
|
| gptkbp:analysis |
intention-to-treat analysis
statistical significance tested |
| gptkbp:business_model |
obtained from institutional review boards
|
| gptkbp:clinical_trial |
gptkb:Clinical_Trials.gov
Phase III 8 years total limited impact on clinical practice |
| gptkbp:collaborator |
gptkb:Harvard_Medical_School
|
| gptkbp:collection |
clinical assessments and surveys
self-reported questionnaires |
| gptkbp:concluded_on |
no conclusive evidence for routine supplementation
|
| gptkbp:criteria |
current use of vitamin D or omega-3 supplements
no prior cardiovascular disease |
| gptkbp:dosage_form |
1 gram of omega-3 fatty acids
2000 IU of vitamin D |
| gptkbp:end_date |
gptkb:2018
|
| gptkbp:focus |
vitamin D and omega-3 fatty acids
|
| gptkbp:follow-up_duration |
5 years
|
| gptkbp:funding |
gptkb:National_Institutes_of_Health
private and public sources |
| gptkbp:future_prospects |
needed to explore other health outcomes.
|
| gptkbp:goal |
to assess the effects on cardiovascular disease
|
| gptkbp:has_implications_for |
guidance for dietary supplementation
|
| https://www.w3.org/2000/01/rdf-schema#label |
The VITAL Trial
|
| gptkbp:impact |
influenced future studies on supplements
|
| gptkbp:investigates |
gptkb:Jo_Ann_E._Manson
|
| gptkbp:is_studied_in |
multicenter trial
|
| gptkbp:location |
gptkb:United_States
|
| gptkbp:notable_work |
no significant effect on cancer risk
suggests vitamin D may not prevent heart disease omega-3 fatty acids did not reduce cardiovascular events |
| gptkbp:participants |
mortality rates
quality of life assessments cancer incidence hospitalization for cardiovascular events major cardiovascular events over 25,000 adults |
| gptkbp:prevention |
randomized controlled trial
|
| gptkbp:provides_information_on |
data available for further research
|
| gptkbp:public_health_relevance |
guides recommendations for older adults
|
| gptkbp:publication |
gptkb:New_England_Journal_of_Medicine
|
| gptkbp:publication_year |
gptkb:2019
|
| gptkbp:research |
double-blind study
|
| gptkbp:result |
no significant reduction in cardiovascular events
|
| gptkbp:sampled_in |
participants assigned to treatment or placebo
|
| gptkbp:side_effect |
monitored throughout the study
|
| gptkbp:sponsor |
gptkb:Brigham_and_Women's_Hospital
|
| gptkbp:start_date |
gptkb:2010
|
| gptkbp:study_findings |
contributed to understanding of dietary supplements
|
| gptkbp:study_population |
diverse demographic groups
|
| gptkbp:topics |
gptkb:D-Health_Trial
gptkb:OMEGA_Trial gptkb:WHI_Trial VITAL-2 Trial |
| gptkbp:bfsParent |
gptkb:The_New_England_Journal_of_Medicine
|
| gptkbp:bfsLayer |
6
|