Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:neurodegenerative_diseases
|
| gptkbp:affects |
gptkb:Heart
gptkb:computer kidneys |
| gptkbp:associated_with |
gptkb:familial_amyloid_polyneuropathy
chronic inflammatory conditions systemic diseases other amyloid types senile systemic amyloidosis |
| gptkbp:caused_by |
transthyretin protein misfolding
|
| gptkbp:clinical_trial |
ongoing studies
phase 3 trials drug repurposing studies |
| gptkbp:diagnosis |
genetic testing
imaging studies biopsy depends on stage variable outcomes depends on organ involvement serum biomarkers |
| gptkbp:first_described_by |
gptkb:1980s
|
| gptkbp:genetic_studies |
mutations in TTR gene
|
| gptkbp:historical_significance |
development of targeted therapies
advancements in diagnostics increased research interest |
| https://www.w3.org/2000/01/rdf-schema#label |
TTR amyloidosis
|
| gptkbp:is_common_in |
certain ethnic groups
older adults |
| gptkbp:pathway |
tissue damage
organ dysfunction amyloid deposits |
| gptkbp:prevalence |
rare disease
|
| gptkbp:public_awareness |
patient advocacy groups
medical education initiatives increasing awareness |
| gptkbp:research_focus |
treatment efficacy
genetic therapies amyloid fibril formation |
| gptkbp:risk_factor |
age
family history certain genetic mutations |
| gptkbp:symptoms |
gptkb:Cardiology
peripheral neuropathy orthostatic hypotension |
| gptkbp:treatment |
gptkb:diflunisal
gptkb:tafamidis improving quality of life symptom management liver transplantation disease stabilization |
| gptkbp:bfsParent |
gptkb:familial_amyloid_polyneuropathy
|
| gptkbp:bfsLayer |
7
|