Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
telomere length regulation
|
| gptkbp:challenges |
genomic instability
|
| gptkbp:conservation |
many eukaryotic species
|
| gptkbp:discovered_by |
researchers in telomere biology
|
| gptkbp:function |
telomere protection
|
| gptkbp:genetic_studies |
linked to cancer
|
| gptkbp:has_role |
cellular senescence
|
| gptkbp:has_website |
Myb-like domain
|
| https://www.w3.org/2000/01/rdf-schema#label |
TRF2
|
| gptkbp:initiated_by |
apoptosis in cells
homologous recombination at telomeres |
| gptkbp:interacts_with |
telomeric DNA
|
| gptkbp:involved_in |
DNA repair
|
| gptkbp:is_associated_with |
cell proliferation
cellular stress response cellular aging telomere dysfunction |
| gptkbp:is_essential_for |
cellular lifespan
|
| gptkbp:is_expressed_in |
gptkb:Cell
various tissues varies during cell cycle |
| gptkbp:is_involved_in |
DNA damage response
cell cycle regulation cellular homeostasis chromatin remodeling stress response tumor suppression cellular differentiation genetic stability telomere maintenance nuclear organization genomic integrity chromosome end protection chromosome stability |
| gptkbp:is_linked_to |
age-related diseases
cancer progression telomere shortening telomere biology telomere maintenance mechanisms |
| gptkbp:is_part_of |
nuclear structure
shelterin complex telomere complex telomere protection complex |
| gptkbp:is_regulated_by |
phosphorylation
telomere length |
| gptkbp:is_studied_for |
therapeutic targets
|
| gptkbp:is_studied_in |
molecular biology
cancer research |
| gptkbp:is_targeted_at |
certain cancer therapies
|
| gptkbp:knockouts |
double-stranded telomeric DNA
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:overexpression_effects |
tumorigenesis
|
| gptkbp:promoter |
TERF2
|
| gptkbp:regulates |
telomerase activity
|
| gptkbp:role |
aging process
|