Statements (79)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
Hedgehog signaling pathway
|
| gptkbp:code |
smoothened protein
|
| gptkbp:conservation |
vertebrates
|
| gptkbp:function |
transmembrane receptor
|
| gptkbp:genetic_studies |
gptkb:Oncology
medulloblastoma |
| gptkbp:has_role |
developmental processes
|
| gptkbp:has_variants |
Smo A1
Smo M2 |
| https://www.w3.org/2000/01/rdf-schema#label |
SMO gene
|
| gptkbp:interacts_with |
PTCH1 protein
|
| gptkbp:involved_in |
cell differentiation
cell growth |
| gptkbp:is_associated_with |
gptkb:embryonic_development
genetic predisposition chronic inflammation metastasis tumor progression medication response |
| gptkbp:is_essential_for |
neural development
|
| gptkbp:is_expressed_in |
embryogenesis
cancer cells embryonic tissues adult tissues muscle tissues neural tissues skin tissues placental tissues lung tissues adipose tissues gastrointestinal tissues |
| gptkbp:is_involved_in |
cell proliferation
cell signaling cellular stress response immune response tumorigenesis cellular differentiation neurogenesis organogenesis cell migration stem cell maintenance vascular development cell fate determination neoplasia cellular repair mechanisms neural crest development tissue patterning |
| gptkbp:is_linked_to |
cellular homeostasis
metabolic disorders therapeutic interventions chronic diseases developmental disorders aging processes cancer therapies drug resistance genetic syndromes |
| gptkbp:is_part_of |
signal transduction pathways
cellular signaling pathways cellular growth pathways embryonic signaling pathways developmental signaling networks |
| gptkbp:is_regulated_by |
hormonal signals
extracellular signals GLI transcription factors Hedgehog ligands micro RNAs |
| gptkbp:is_studied_for |
therapeutic targets
biomarker potential |
| gptkbp:is_studied_in |
cancer research
genetic research therapeutic development |
| gptkbp:is_targeted_at |
small molecule inhibitors
|
| gptkbp:located_in |
human chromosome 7
|
| gptkbp:part_of |
Hedgehog signaling pathway
|
| gptkbp:regulates |
gene expression
|
| gptkbp:targets |
SMO inhibitors
|
| gptkbp:bfsParent |
gptkb:BCC_IV
|
| gptkbp:bfsLayer |
8
|