Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:bfsLayer |
8
|
| gptkbp:bfsParent |
gptkb:Rho_A
|
| gptkbp:agent |
gptkb:Rho_A
|
| gptkbp:associated_with |
gptkb:psychologist
cardiovascular diseases cancer progression |
| gptkbp:discovered_by |
1990s
|
| gptkbp:established |
Fasudil
GS K269962 A HA-1077 Rho-kinase inhibitors S R3677 Sphingosine kinase inhibitors Sphingosine-1-phosphate Y-27632 N-(4-(1 H-imidazol-4-yl)phenyl)-2-(4-(trifluoromethyl)phenyl)thiazole-4-carboxamide |
| gptkbp:function |
regulates contraction of smooth muscle
|
| https://www.w3.org/2000/01/rdf-schema#label |
Rho-kinase
|
| gptkbp:is_a_route_for |
apoptosis regulation
cell motility cell proliferation wound healing fibrosis angiogenesis inflammation response stress fiber formation Rho signaling pathway actin cytoskeleton regulation tight junction formation |
| gptkbp:is_involved_in |
gptkb:sneaker
gptkb:psychologist Huntington's disease stroke cytoskeletal organization heart failure neuroinflammation traumatic brain injury arrhythmias cardiac hypertrophy pulmonary hypertension pulmonary fibrosis atherosclerosis cell migration kidney diseases retinal diseases chronic obstructive pulmonary disease spinal cord injury diabetes complications ischemia-reperfusion injury tumor metastasis liver fibrosis |
| gptkbp:location |
cytoplasm
cell membrane |
| gptkbp:material |
cofilin
filamin myosin light chain |
| gptkbp:promoter |
ROC K1
ROC K2 |
| gptkbp:role |
cell adhesion
neurite retraction vascular smooth muscle contraction |