Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:code |
gptkb:human_chromosome_16
|
| gptkbp:contains_domain |
UBM domain
|
| gptkbp:function |
DNA damage response
|
| gptkbp:has_function |
protein-protein interactions
|
| gptkbp:has_role |
cellular response to stress
tumor suppression |
| https://www.w3.org/2000/01/rdf-schema#label |
RAP80
|
| gptkbp:interacts_with |
gptkb:BRCA1
|
| gptkbp:involved_in |
DNA repair
|
| gptkbp:is_associated_with |
tumorigenesis
tumor progression cellular signaling dysregulation response to ionizing radiation chemosensitivity |
| gptkbp:is_essential_for |
genomic stability
|
| gptkbp:is_expressed_in |
gptkb:Cell
various tissues cellular differentiation cancerous tissues |
| gptkbp:is_involved_in |
apoptosis regulation
cellular homeostasis cellular stress response chromatin remodeling homologous recombination chromosomal stability cell cycle checkpoints cellular signaling pathways cellular repair mechanisms tumor microenvironment interactions repair of double-strand breaks cellular repair of oxidative damage cellular repair response to UV damage cellular response to DNA damage. genomic integrity maintenance |
| gptkbp:is_linked_to |
cellular proliferation
cellular aging genetic predisposition to cancer cancer metastasis oncogenic processes |
| gptkbp:is_part_of |
DNA damage signaling pathway
DNA repair machinery nuclear foci during DNA damage response nuclear repair foci protein complexes involved in DNA repair protein complexes regulating DNA damage response BRCA1-A complex BRCA1-dependent pathways |
| gptkbp:is_regulated_by |
post-translational modifications
|
| gptkbp:is_studied_for |
biomarker potential
cancer therapy development therapeutic targeting |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
therapeutic agents
|
| gptkbp:located_in |
gptkb:Atom
|
| gptkbp:orthologs |
other species
|
| gptkbp:promoter |
RAP80 gene
|
| gptkbp:regulates |
cell cycle progression
|
| gptkbp:weight |
approximately 80 k Da
|