Statements (73)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:affects |
cellular homeostasis
cellular metabolism immune response hormonal regulation tumor suppressor function neurodevelopment cellular signaling networks |
| gptkbp:amended_by |
cell cycle regulation
|
| gptkbp:can_cause |
neoplasia
|
| gptkbp:can_detect |
genetic testing
|
| gptkbp:can_lead_to |
cellular senescence
tumorigenesis increased cell proliferation increased oxidative stress increased angiogenesis increased metastasis increased inflammation increased cell growth |
| gptkbp:can_result_in |
macrocephaly
loss of function altered gene expression abnormal cell signaling dysregulated signaling pathways |
| gptkbp:caused_by |
environmental factors
|
| gptkbp:has_a_focus_on |
clinical trials
molecular diagnostics |
| https://www.w3.org/2000/01/rdf-schema#label |
PTEN gene mutation
|
| gptkbp:influence |
therapeutic outcomes
tumor progression response to treatment tumor microenvironment interactions cancer progression. |
| gptkbp:inherits_from |
autosomal dominant trait
|
| gptkbp:is_a_subject_of |
genomic studies
biomarker research |
| gptkbp:is_associated_with |
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease age-related diseases metabolic disorders chronic diseases metabolic syndrome cardiovascular diseases autism spectrum disorders neurocognitive disorders |
| gptkbp:is_characterized_by |
altered protein function
|
| gptkbp:is_found_in |
various cancers
|
| gptkbp:is_involved_in |
apoptosis regulation
cellular stress response DNA repair mechanisms cell signaling pathways tumor microenvironment cellular differentiation tumor immunity tumor suppressor pathways |
| gptkbp:is_linked_to |
gptkb:Oncology
gptkb:neurofibromatosis epigenetic changes endometrial cancer chronic inflammation vascular malformations gastrointestinal cancers |
| gptkbp:is_studied_for |
targeted therapies
therapeutic resistance preventive strategies |
| gptkbp:is_studied_in |
cancer research
pharmacogenomics |
| gptkbp:risk_factor |
hereditary cancer syndromes
|
| gptkbp:targets |
gptkb:gene_therapy
|
| gptkbp:treatment |
targeted therapies
|
| gptkbp:type_of |
somatic mutation
|
| gptkbp:bfsParent |
gptkb:Proteus_syndrome
|
| gptkbp:bfsLayer |
5
|