Statements (74)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:affects |
cellular homeostasis
cellular metabolism immune response hormonal regulation tumor suppressor function neurodevelopment cellular signaling networks |
| gptkbp:amended_by |
cell cycle regulation
|
| gptkbp:can_be |
macrocephaly
loss of function altered gene expression abnormal cell signaling dysregulated signaling pathways |
| gptkbp:can_lead_to |
cellular senescence
tumorigenesis increased cell proliferation increased oxidative stress increased angiogenesis increased metastasis increased inflammation increased cell growth |
| gptkbp:caused_by |
environmental factors
neoplasia |
| gptkbp:descendant |
autosomal dominant trait
|
| gptkbp:focuses_on |
clinical trials
molecular diagnostics |
| https://www.w3.org/2000/01/rdf-schema#label |
PTEN gene mutation
|
| gptkbp:influence |
therapeutic outcomes
tumor progression response to treatment tumor microenvironment interactions cancer progression. |
| gptkbp:is_associated_with |
gptkb:Cowden_syndrome
gptkb:Lhermitte-Duclos_disease age-related diseases metabolic disorders chronic diseases metabolic syndrome cardiovascular diseases autism spectrum disorders neurocognitive disorders |
| gptkbp:is_characterized_by |
altered protein function
|
| gptkbp:is_found_in |
various cancers
|
| gptkbp:is_involved_in |
apoptosis regulation
cellular stress response DNA repair mechanisms cell signaling pathways tumor microenvironment cellular differentiation tumor immunity tumor suppressor pathways |
| gptkbp:is_linked_to |
gptkb:healthcare_organization
gptkb:psychologist epigenetic changes endometrial cancer chronic inflammation vascular malformations gastrointestinal cancers |
| gptkbp:is_studied_in |
cancer research
targeted therapies pharmacogenomics therapeutic resistance preventive strategies |
| gptkbp:recognizes |
genetic testing
|
| gptkbp:risk_factor |
hereditary cancer syndromes
|
| gptkbp:subject |
genomic studies
biomarker research |
| gptkbp:targets |
gptkb:physicist
|
| gptkbp:treatment |
targeted therapies
|
| gptkbp:type_of |
somatic mutation
|
| gptkbp:bfsParent |
gptkb:Cowden_syndrome
gptkb:Proteus_syndrome |
| gptkbp:bfsLayer |
5
|