Statements (61)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:drug
|
| gptkbp:activities |
increases insulin secretion
increases insulin sensitivity decreases hepatic glucose production |
| gptkbp:appointed_by |
oral tablet
|
| gptkbp:approves |
gptkb:2007
gptkb:FDA |
| gptkbp:brand |
gptkb:Janumet_100/1000
gptkb:Janumet_50/1000 gptkb:Janumet_XR |
| gptkbp:class |
antidiabetic agent
biguanide and DPP-4 inhibitor |
| gptkbp:clinical_trial |
various studies
glycemic control |
| gptkbp:contains |
gptkb:sitagliptin
gptkb:metformin |
| gptkbp:contraindication |
gptkb:healthcare_organization
liver disease hypersensitivity to components |
| gptkbp:dosage_form |
gptkb:tablet
100/1000 mg 50/1000 mg |
| gptkbp:education |
take with food
report any unusual symptoms |
| gptkbp:formulation |
combination therapy
|
| gptkbp:has_ability |
100 mg/1000 mg
50 mg sitagliptin and 1000 mg metformin 50 mg/1000 mg |
| https://www.w3.org/2000/01/rdf-schema#label |
Janumet
|
| gptkbp:interacts_with |
gptkb:beer
other diabetes medications |
| gptkbp:is_available_in |
gptkb:various_countries
|
| gptkbp:is_monitored_by |
renal function
liver function blood glucose levels |
| gptkbp:is_used_for |
type 2 diabetes
|
| gptkbp:manufacturer |
gptkb:Merck_&_Co.
|
| gptkbp:marketed_as |
various brand names
|
| gptkbp:pharmacokinetics |
excreted in urine
absorbed in gastrointestinal tract metabolized in liver |
| gptkbp:population |
adults with type 2 diabetes
|
| gptkbp:provides_information_on |
ADA Standards of Medical Care
AACE Diabetes Management Guidelines |
| gptkbp:requires |
gptkb:theorem
|
| gptkbp:safety_features |
not recommended during breastfeeding
not recommended during pregnancy monitor for signs of lactic acidosis |
| gptkbp:shelf_life |
2 to 3 years
|
| gptkbp:side_effect |
nausea
diarrhea stomach pain hypoglycemia vitamin B12 deficiency pancreatitis |
| gptkbp:storage |
room temperature
|
| gptkbp:treatment |
part of a comprehensive diabetes management plan
|
| gptkbp:type_of_care |
important for effectiveness
|
| gptkbp:bfsParent |
gptkb:Dapagliflozin/_Metformin/_Sitagliptin
gptkb:Glucophage |
| gptkbp:bfsLayer |
5
|