Statements (237)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
age-related diseases metabolic disorders chronic diseases metastasis tumor progression cancer progression in mice chronic diseases in mice chronic hypoxia disease progression in mice metabolic syndrome in mice |
| gptkbp:code |
gptkb:hypoxia-inducible_factor_1-alpha
|
| gptkbp:community |
inflammatory response
|
| gptkbp:function |
regulates cellular response to hypoxia
|
| gptkbp:genetic_studies |
various diseases
various cancers cancers |
| gptkbp:has_function |
gptkb:DNA
|
| gptkbp:has_role |
angiogenesis
neuroprotection tumor progression |
| gptkbp:has_variants |
HIF1 A polymorphisms
|
| https://www.w3.org/2000/01/rdf-schema#label |
HIF1 A
|
| gptkbp:influences |
metabolism
cell differentiation cell proliferation cellular homeostasis glucose metabolism immune response metabolic pathways inflammation fibrosis oxidative stress response tissue regeneration neurogenesis vascular remodeling tissue repair cell migration vascular health tissue homeostasis metabolic adaptation cellular repair mechanisms metabolic reprogramming cellular growth factors tissue oxygenation tissue repair processes |
| gptkbp:initiated_by |
apoptosis
growth factors low oxygen levels prolyl hydroxylases low oxygen conditions normoxia |
| gptkbp:interacts_with |
gptkb:SIRT1
gptkb:NF-k_B p300 hypoxia-responsive elements HIF1 B HIF1 A co-factors HIF1 A inhibitors HIF1 A regulators HIF1 A signaling molecules HIF1 A signaling partners HIF1 A target genes |
| gptkbp:involved_in |
metabolism
developmental processes cardiovascular diseases tumor microenvironment angiogenesis erythropoiesis stem cell maintenance cellular signaling metabolic adaptation neovascularization cellular adaptation mechanisms cellular signaling networks cellular response to hypoxia cancer therapy resistance cellular adaptation to hypoxia |
| gptkbp:is_associated_with |
metabolic disorders
autoimmune diseases chronic diseases metabolic syndrome obesity cardiovascular diseases chronic kidney disease pulmonary hypertension chronic inflammation ischemia metastasis chronic obstructive pulmonary disease neoplasia neoplastic transformation |
| gptkbp:is_essential_for |
adaptation to hypoxia
cell survival under hypoxia |
| gptkbp:is_expressed_in |
gptkb:Brain
gptkb:developers gptkb:Skin gptkb:Heart hypoxic conditions liver muscle tissue pancreas placenta various tissues adipose tissue tumor microenvironment endothelial cells gastrointestinal tract spleen tumor cells placental tissues adipose tissues brain tissues liver tissues various human tissues kidney tissues hypoxic tissues |
| gptkbp:is_involved_in |
gptkb:diabetes
gptkb:neurodegenerative_diseases aging cell differentiation cell proliferation cellular metabolism cellular stress response immune response inflammation metabolic syndrome obesity wound healing liver disease fibrosis stem cell biology cancer biology cellular senescence chronic kidney disease cell survival oxidative stress response tumor heterogeneity tumor microenvironment pulmonary hypertension vascular remodeling tissue repair renal function neuroprotection cell migration metastasis stem cell maintenance cellular signaling pulmonary diseases tumor progression cancer stem cells therapeutic resistance muscle adaptation neoplasia cellular adaptation tumor angiogenesis immune evasion tumor microenvironment interactions neovascularization cancer cachexia metabolic reprogramming tumor immune interactions epithelial-mesenchymal transition endothelial function tumor metastasis tumor metabolism tumor evolution cell invasion metastatic niche formation tumor microenvironment remodeling tumor recurrence tumor immune response tumor dormancy hypoxia-induced apoptosis hypoxia-induced gene expression neurovascular regulation |
| gptkbp:is_linked_to |
gptkb:diabetes
metabolic disorders cardiovascular diseases chronic inflammation ischemia inflammatory diseases chronic hypoxia |
| gptkbp:is_part_of |
hypoxia signaling pathway
hypoxia-inducible factor complex |
| gptkbp:is_regulated_by |
gptkb:hypoxia-inducible_factor_1-beta
transcription factors epigenetic modifications hypoxia-inducible factors oxygen levels prolyl hydroxylases micro RNAs |
| gptkbp:is_studied_for |
therapeutic interventions
|
| gptkbp:is_studied_in |
metabolic syndrome
clinical research cardiac research rat models rat models of disease |
| gptkbp:is_targeted_at |
gptkb:gene_therapy
therapeutic agents |
| gptkbp:knockouts |
HRE (hypoxia response element)
|
| gptkbp:located_in |
gptkb:Atom
human chromosome 14 |
| gptkbp:orthologs |
other species
HIF1 A in humans HIF1 A in mice HIF1 A in rats |
| gptkbp:promotes |
glucose metabolism
glucose uptake |
| gptkbp:regulates |
cell cycle progression
cell proliferation cellular energy metabolism cellular stress response iron metabolism lipid metabolism neuroinflammation extracellular matrix remodeling erythropoiesis cellular signaling pathways angiogenic factors cellular differentiation pathways cellular metabolic pathways cellular adaptation to stress cellular growth cellular survival pathways immune cell function apoptotic pathways VEGF expression hypoxia-induced responses hypoxia-inducible factor pathway hypoxia-related genes oxygen homeostasis |
| gptkbp:regulates_expression_of |
VEGF
|
| gptkbp:targets |
anti-cancer therapies
|
| gptkbp:bfsParent |
gptkb:HOT3
|
| gptkbp:bfsLayer |
5
|