Statements (111)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:virus
|
| gptkbp:breeding_behavior |
other flaviviruses
|
| gptkbp:can_detect |
infected liver tissue
|
| gptkbp:code |
gptkb:NS5_A_gene
|
| gptkbp:function |
viral replication
|
| gptkbp:has_role |
resistance to treatment
|
| gptkbp:has_variants |
resistant variants
|
| https://www.w3.org/2000/01/rdf-schema#label |
HCV NS5 A protein
|
| gptkbp:initiated_by |
interferon signaling
|
| gptkbp:interacts_with |
host cell proteins
|
| gptkbp:involved_in |
viral assembly
|
| gptkbp:is_analyzed_in |
mass spectrometry
|
| gptkbp:is_associated_with |
treatment failure
treatment outcomes treatment regimens chronic infection management chronic liver disease genotype variations treatment response variability viral load fluctuations |
| gptkbp:is_characterized_by |
post-translational modifications
protein stability protein folding protein-protein interactions conformational changes functional domains phosphorylation sites protein interactions with host factors protein interactions with viral components protein stability dynamics |
| gptkbp:is_essential_for |
HCV life cycle
|
| gptkbp:is_expressed_in |
acute infection
liver cells infected cells chronic infection infected hepatocytes infected liver cells infected tissues viral infection phases viral replication phases |
| gptkbp:is_involved_in |
cell signaling pathways
immune response modulation immune evasion viral pathogenesis viral pathogenesis studies viral entry viral entry mechanisms viral pathogenesis mechanisms viral persistence viral protein synthesis viral immune evasion strategies viral entry processes viral genome replication viral genome stability viral immune response modulation viral load determination viral pathogenesis mechanisms. viral pathogenesis research viral persistence mechanisms viral persistence studies viral replication control viral replication dynamics |
| gptkbp:is_linked_to |
gptkb:hepatocellular_carcinoma
cirrhosis liver transplantation co-infections chronic hepatitis C extrahepatic manifestations liver fibrosis liver disease progression chronic infection complications liver cancer risk liver disease outcomes |
| gptkbp:is_part_of |
HCV genome
viral assembly processes viral envelope formation viral life cycle processes viral life cycle stages viral protein complexes viral replication complex viral replication machinery viral replication systems |
| gptkbp:is_regulated_by |
host factors
|
| gptkbp:is_studied_for |
clinical outcomes
therapeutic efficacy vaccine development therapeutic targets clinical implications drug resistance mechanisms diagnostic markers |
| gptkbp:is_studied_in |
clinical trials
biomedical research laboratory settings clinical research trials experimental models |
| gptkbp:is_targeted_at |
combination therapy
therapeutic interventions new antiviral agents targeted therapies combination therapies emerging therapies novel therapies antiviral strategies direct-acting antivirals new antiviral strategies |
| gptkbp:location |
cytoplasm
|
| gptkbp:targets |
monoclonal antibodies
antiviral drugs |
| gptkbp:bfsParent |
gptkb:pibrentasvir
|
| gptkbp:bfsLayer |
5
|