Statements (57)
Predicate | Object |
---|---|
gptkbp:instance_of |
gptkb:drug
|
gptkbp:activities |
fusion inhibitor
prevents viral entry into cells |
gptkbp:appointed_by |
subcutaneous injection
|
gptkbp:approves |
gptkb:2003
gptkb:FDA |
gptkbp:availability |
prescription only
|
gptkbp:brand |
Fuzeon
|
gptkbp:can_be_used_with |
other antiretroviral agents
|
gptkbp:class |
HIV fusion inhibitors
|
gptkbp:clinical_trial |
Phase III
HIV infection ongoing for new indications |
gptkbp:contraindication |
hypersensitivity to the drug
|
gptkbp:developed_by |
Trimeris
|
gptkbp:dosage_form |
lyophilized powder for injection
|
gptkbp:duration |
long-term therapy
|
gptkbp:education |
necessary for proper use
|
gptkbp:established |
gp41 protein
|
gptkbp:formulation |
injectable
powder for reconstitution |
https://www.w3.org/2000/01/rdf-schema#label |
Enfuvirtide
|
gptkbp:indication |
treatment-experienced HIV patients
|
gptkbp:ingredients |
gptkb:Enfuvirtide
C37 H48 N6 O9 S |
gptkbp:interacts_with |
none significant
|
gptkbp:invention |
patented
|
gptkbp:is_monitored_by |
regular follow-up required
|
gptkbp:is_used_for |
treatment of HIV
|
gptkbp:lifespan |
3.8 hours
|
gptkbp:manager |
subcutaneous
|
gptkbp:marketed_as |
gptkb:Roche
|
gptkbp:pharmacokinetics |
subcutaneous absorption
inhibits HIV fusion process |
gptkbp:population |
adults and children
|
gptkbp:price |
expensive
|
gptkbp:provides_access_to |
limited in some regions
|
gptkbp:provides_information_on |
included in treatment guidelines
part of combination therapy |
gptkbp:research_focus |
HIV resistance
|
gptkbp:rounds |
renal
|
gptkbp:safety_features |
generally well tolerated
|
gptkbp:side_effect |
fatigue
nausea diarrhea injection site reactions increased risk of bacterial pneumonia |
gptkbp:status |
ongoing studies
|
gptkbp:storage |
refrigerated
|
gptkbp:supply_chain |
complex logistics required
|
gptkbp:targets |
HIV-1 virus
|
gptkbp:traded_on |
Fuzeon
|
gptkbp:type_of_care |
important for effectiveness
|
gptkbp:weight |
659.96 g/mol
|
gptkbp:year_created |
gptkb:1992
|
gptkbp:bfsParent |
gptkb:Burroughs_Wellcome
|
gptkbp:bfsLayer |
4
|