Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:affects |
EGFR protein
|
| gptkbp:analyzes |
therapeutic strategies
molecular pathology novel therapies |
| gptkbp:associated_with |
gptkb:healthcare_organization
|
| gptkbp:can_lead_to |
disease progression
increased cell proliferation |
| gptkbp:caused_by |
resistance to EGFR inhibitors
|
| gptkbp:discovered_by |
gptkb:2015
|
| gptkbp:examines |
genetic testing
clinical outcomes survival outcomes |
| https://www.w3.org/2000/01/rdf-schema#label |
EGFR T790 M mutation
|
| gptkbp:influences |
treatment decisions
|
| gptkbp:is_a |
secondary mutation
|
| gptkbp:is_aimed_at |
gptkb:osimertinib
|
| gptkbp:is_analyzed_in |
bioinformatics tools
therapeutic efficacy clinical significance |
| gptkbp:is_associated_with |
increased tumor aggressiveness
poor response to treatment adverse effects of treatment acquired resistance |
| gptkbp:is_characterized_by |
threonine to methionine substitution
|
| gptkbp:is_considered |
personalized medicine
treatment planning patient management patient stratification |
| gptkbp:is_considered_as |
a significant finding
|
| gptkbp:is_documented_in |
clinical records
oncology databases |
| gptkbp:is_evaluated_by |
diagnostic tests
therapeutic trials |
| gptkbp:is_found_in |
tumor samples
|
| gptkbp:is_linked_to |
tumor heterogeneity
treatment failure increased mortality risk poor prognosis treatment resistance mechanisms |
| gptkbp:is_monitored_by |
patient follow-up
|
| gptkbp:is_noted_for |
case studies
high mutation rate its role in therapy resistance |
| gptkbp:is_often_used_in |
Asian populations
|
| gptkbp:is_part_of |
precision oncology
cancer genomics cancer biomarkers EGFR signaling pathway |
| gptkbp:is_popular_in |
approximately 50% in resistant cases
|
| gptkbp:is_recognized_by |
next-generation sequencing
a key biomarker |
| gptkbp:is_related_to |
EGFR L858 R mutation
|
| gptkbp:is_studied_in |
molecular genetics
oncology research mechanisms of resistance |
| gptkbp:is_subject_to |
research studies
|
| gptkbp:is_tested_for |
clinical trials
|
| gptkbp:is_utilized_in |
gptkb:municipality
|
| gptkbp:occurs_in |
lung tissue
|
| gptkbp:recognizes |
gptkb:item
biopsy |
| gptkbp:reports_to |
gptkb:academic_journal
|
| gptkbp:resulted_in |
altered signaling pathways
|
| gptkbp:treatment |
targeted therapy
|
| gptkbp:type_of |
point mutation
|
| gptkbp:bfsParent |
gptkb:Tagrisso
|
| gptkbp:bfsLayer |
4
|